EEG source activity during processing of neutral stimuli in subjects with anxiety disorders

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Acta Neurobiologiae Experimentalis

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Subject: Behavioral Sciences , Biomedical Sciences & Nutrition , Life Sciences , Medicine , Neurosciences

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VOLUME 76 , ISSUE 1 (March 2016) > List of articles

Advertisement EEG source activity during processing of neutral stimuli in subjects with anxiety disorders

Bartłomiej Gmaj / Piotr Januszko / Jan Kamiński / Ewa Drozdowicz / Maciej Kopera / Dorota Wołyńczyk-Gmaj * / Waldemar Szelenberger / Marcin Wojnar

Keywords : endogenous evoked potentials, anxiety disorders, enhanced electrophysiological activation, LORETA

Citation Information : Acta Neurobiologiae Experimentalis. Volume 76, Issue 1, Pages 75-85, DOI: https://doi.org/10.21307/ane-2017-007

License : (CC BY 4.0)

Received Date : 18-January-2016 / Accepted: 23-March-2016 / Published Online: 25-July-2017

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ABSTRACT

Anxiety disorders are a social problem due to their prevalence and consequences. It is crucial to explore the influence of anxiety on cognitive processes. In this study we recorded EEG activity from 73 subjects (35 patients, 38 controls, matched for age and education)during performance of the Continuous Attention Task. We used low resolution electromagnetic tomography (LORETA) for evaluation of mechanisms of impaired cognitive performance in anxiety disorders. Analysis showed that patients with anxiety disorders committed more errors than the controls, had a short latency of P300 and higher amplitude of ERPs at all steps of stimulus processing. Furthermore, we showed that there was a relationship between the scores of Hamilton Anxiety Scale and Beck Depression Inventory, and amplitudes and latencies of ERPs. The results of LORETA analysis showed that enhanced neural responses were found within circuits mediating visual information processing, sustained attention and anxiety. Also, we found higher current density within areas playing an important role in
the brain fear network – anterior cingulate and anterior part of insula. Electrophysiological neuroimaging showed greater recruitment of cognitive resources in anxiety disorders, evidenced by higher current density and activation of greater number of brain areas. Despite the strategy employed to compensate for cognitive problems, the anxiety patients did not achieve the same performance as controls. Present study demonstrates that anxiety disorders influence processing of neutral stimuli and this influence is observable at both behavioral and electrophysiological level. The data suggests instability of neural systems responsible for information selection, working memory, engagement and focusing of attention.

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REFERENCES

  1. Aigner M, Sachs G, Bruckmüller E, Winklbaur B, Zitterl W, Kryspin-Exner I, Gur R, Katschnig H (2007) Cognitive and emotion recognition deficits in obsessive-compulsive disorder. Psychiatry Res 149: 121–128.
  2. Albert CM, Chae CU, Rexrode KM, Manson JE, Kawachi I (2005) Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women. Circulation 111: 480–487.
  3. Andreou C, Leicht G, Popescu V, Pogarell O, Mavrogiorgou P, Rujescu D, Giegling I, Zaudig M, Juckel G, Hegerl U, Mulert C (2013) P300 in obsessive-compulsive disorder: source localization and the effects of treatment. J Psychiatr Res 47(12): 1975–1983.
  4. Attias J, Bleich A, Furman V, Zinger Y (1996) Event-related potentials in post-traumatic stress disorder of combat origin. Biol Psychiatry 40: 373–381.
  5. Baving L, Rellum T, Laucht M, Schmidt MH (2004) Attentional enhancement to NoGo stimuli in anxious children. J Neural Transm 111: 985–999.
  6. Beck A, Ward C, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4: 561–571.
  7. Bremner JD, Vermetten E, Schmahl C, Vaccarino V, Vythilingam M, Afzal N, Grillon C, Charney DS (2005) Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder. Psychol Med 35: 791–806.
  8. Brühl AB, Delsignore A, Komossa K, Weidt S (2014) Neuroimaging in Social Anxiety Disorder – a meta-analytic review resulting in a new neurofunctional model. Neurosci Biobehav Rev 47: 260–280.
  9. Carretié L, Hinojosa JA, Martín-Loeches M, Mercado F, Tapia M (2004) Automatic attention to emotional stimuli: Neural correlates. Hum Brain Mapp 22: 290–299.
  10. Chantarujikapong SI, Scherrer JF, Xian H, Eisen SA, Lyons MJ, Goldberg J, Tsuang M, True WR (2001) A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men. Psychiatry Res 103: 133–145.
  11. Clark CR, Galletly CA, Ash DJ, Moores KA, Penrose RA, McFarlane AC (2009) Evidence-based medicine evaluation of electrophysiological studies of the anxiety disorders. Clin EEG Neurosci 40: 84–112.
  12. Critchley HD, Mathias CJ, Dolan RJ (2002) Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy. Neuron 33: 653–663.
  13. de Graaf R, Ten Have M, van Gool C, van Dorsselaer S (2012) Prevalence of mental disorders and trends from 1996 to 2009. Results from the Netherlands Mental Health Survey and Incidence Study-2. Soc Psychiatry Psychiatr Epidemiol 47: 203–213.
  14. De Geus F, Denys DA, Sitskoorn MM, Westenberg HG (2007) Attention and cognition in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci 61: 45–53.
  15. Dilger S, Straube T. Brain activation to phobia-related pictures in spider phobic humans: an event-related functional magnetic resonance imaging study (2003) Neurosci Lett 348: 29–32.
  16. Egloff B, Hock M (2001) Interactive effects of state anxiety and trait anxiety on emotional Stroop interference. Pers Individ Dif 31: 875–882.
  17. Esslen M, Pascual-Marqui RD, Hell D, Kochi K, Lehmann D (2004) Brain areas and time course of emotional processing. Neuroimage 21: 1189–1203.
  18. Eser D, Leicht G, Lutz J, Wenninger S, Kirsch V, Schule C, Karch S, Baghai T, Pogarell O, Born C, Rupprecht R, Mulert C (2009) Functional neuroanatomy of CCK-4-induced panic attacks in healthy volunteers. Hum Brain Mapp 30: 511–522.
  19. Etkin A, Prater KE, Hoeft F, Menon V, Schatzberg AF (2010) Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder. Am J Psychiatry 167: 545–554.
  20. Etkin A, Wager TD (2007) Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 164: 1476–1488.
  21. Eysenck MW, Derakshan N, Santos R, Calvo MG (2007) Anxiety and cognitive performance: attentional control theory. Emotion 7: 336–353.
  22. Ferreri F, Lapp LK, Peretti CS (2011) Current research on cognitive aspects of anxiety disorders. Curr Opin Psychiatry 24: 49–54.
  23. Fischler I, Bradley M (2006) Event-related potential studies of language and emotion: words, phrases, and task effects. Prog Brain Res 156: 185–203.
  24. Foti D, Hajcak G, Dien J (2009) Differentiating neural responses to emotional pictures: Evidence from temporal-spatial PCA. Psychophysiology 46: 521–530.
  25. Fox E, Russo R, Bowles R, Dutton K (2001) Do threatening stimuli draw or hold visual attention in subclinical anxiety. J Exp Psychol Gen 130: 681–700.
  26. Friedman D, Cycowicz YM, Gaeta H (2001) The novelty P3: an event-related brain potential (ERP) sign of the brain’s evaluation of novelty. Neurosci Biobehav Rev 25: 355–373.
  27. Greenberg PE, Sisitsky T, Kessler RC, Finkelstein SN, Berndt ER, Davidson JR, Ballenger JC, Fyer AJ (1999) The economic burden of anxiety disorders in the 1990s. J Clin Psychiatry 60: 427–435.
  28. Hajcak G, McDonald N, Simons RF (2003) Anxiety and error-related brain activity. Biol Psychol 64: 77–90.
  29. Hamilton M (1959) The assessment of anxiety states by rating. Br J Med Psychol 32: 50–55.
  30. Hanatani T, Sumi N, Taguchi S, Fujimoto O, Nan-No H, Takeda M (2005) Event-related potentials in panic disorder and generalized anxiety disorder. Psychiatry Clin Neurosci 59: 83–88.
  31. Heinze HJ, Mangun GR, Burchert W, Hinrichs H, Scholz M, Münte TF, Gös A, Scherg M, Johannes S, Hundeshagen H, Gazzaniga MS, Hillyard SA (1994) Combined spatial and temporal imaging of brain activity during visual selective attention in humans. Nature 372: 543–546.
  32. Herbert C, Junghofer M, Kissler J (2008) Event related potentials to emotional adjectives during reading. Psychophysiology 45: 487–498.
  33. Herrmann MJ, Jacob C, Unterecker S, Fallgatter AJ (2003) Reduced response-inhibition in obsessive-compulsive disorder measured with topographic evoked potential mapping. Psychiatry Res 120: 265–271.
  34. Herrmann MJ, Römmler J, Ehlis AC, Heidrich A, Fallgatter A (2004) J. Source localization (LORETA) of the error-related-negativity (ERN/Ne) and positivity (Pe). Cogn Brain Res 20: 294–299.
  35. Hettema JM, Neale MC, Kendler KS (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158: 1568–1578.
  36. Iwanami A, Kuwakado D, Otsubo T, Ishono H, Kamijima K (1997) Relapse of panic disorder induced by a single intravenous methamphetamine injection. J Anxiety Disord 11: 113–116.
  37. Javanmard M, Shlik J, Kennedy SH, Vaccarino FJ, Houle S, Bradwejn (1999) J. Neuroanatomic correlates of CCK-4-induced panic attacks in healthy humans: a comparison of two time points. Biol Psychiatry 45: 872–882.
  38. Jensen J, McIntosh AR, Crawley AP, Mikulis DJ, Remington G, Kapur S (2003) Direct activation of the ventral striatum in anticipation of aversive stimuli. Neuron 40: 1251–1257.
  39. Johannes S, Wieringa BM, Nager W, Rada D, Dengler R, Emrich HM, Münte TF, Dietrich DE (2001) Discrepant target detection and action monitoring in obsessive-compulsive disorder. Psychiatry Res 108: 101–110.
  40. Kawachi I, Sparrow D, Vokonas PS, Weiss ST (1994a) Symptoms of anxiety and risk of coronary heart disease. The Normative Aging Study. Circulation 90: 2225–2229.
  41. Kawachi I, Colditz GA, Ascherio A, Rimm EB, Giovannucci E, Stampfer MJ, Willett WC (1994b) Prospective study of phobic anxiety and risk of coronary heart disease in men. Circulation 89: 19.
  42. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62: 593–602.
  43. Ketter TA, Andreason PJ, George MS, Lee C, Gill DS, Parekh PI, Willis MW, Herscovitch P, Post RM (1996) Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Arch Gen Psychiatry 53: 59–69.
  44. Kimble M, Kaloupek D, Kaufman M, Deldin P (2000) Stimulus novelty differentially affects attentional allocation in PTSD. Biol Psychiatry 47: 880–890.
  45. Klumpp H, Fitzgerald DA, Angstadt M, Post D, Phan KL (2014) Neural response during attentional control and emotion processing predicts improvement after cognitive behavioral therapy in generalized social anxiety disorder. Psychol Med 44(14): 3109–3121.
  46. Knott V, Lapierre YD, Fraser G, Johnson N (1991) Auditory evoked potentials in panic disorder. J Psychiatry Neurosci 16: 215–220.
  47. Kok A (2001) On the utility of P3 amplitude as a measure of processing capacity. Psychophysiology 38: 557–577.
  48. Kolassa IT, Musial F, Kolassa S, Miltner WH (2006) Event-related potentials when identifying or color-naming threatening schematic stimuli in spider phobic and non-phobic individuals. BMC Psychiatry 6: 38.
  49. Kopřivová J, Congedo M, Horáček J, Praško J, Raszka M, Brunovský M, Kohútová B, Höschl C (2011) EEG source analysis in obsessive-compulsive disorder. Clin Neurophysiol 122: 1735–1743.
  50. Lavric A, Pizzagalli D, Forstmeier S, Rippon G (2001) A double-dissociation of English past-tense production revealed by event-related potentials and low-resolution electromagnetic tomography (LORETA). Clin Neurophysiol 112: 1833–1849.
  51. Lorberbaum JP, Kose S, Johnson MR, Arana GW, Sullivan LK, Hamner MB, Ballenger JC, Lydiard RB, Brodrick PS, Bohning DE, George MS (2004) Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport 15: 2701–2705.
  52. Luck SJ, Hillyard SA, Mouloua M, Woldorff MG, Clark VP, Hawkins HL (1994) Effects of spatial cuing on luminance detectability: psychophysical and electrophysiological evidence for early selection. J Exp Psychol Hum Percept Perform 20: 887–904.
  53. Luck SJ, Woodman GF, Vogel EK (2000) Event-related potential studies of attention. Trends Cogn Sci 4: 432–440.
  54. Mangun GR, Hopfinger JB, Kussmaul CL, Fletcher EM, Heinze HJ (1997) Covariations in ERP and PET measures of spatial selective attention in human extrastriate visual cortex. Hum Brain Mapp 5: 273–279.
  55. Mangun GR, Buonocore MH, Girelli M, Jha AP (1998) ERP and fMRI measures of visual spatial selective attention. Hum Brain Mapp 6: 383–389.
  56. Mavrogiorgou P, Juckel G, Frodl T, Gallinat J, Hauke W, Zaudig M, Dammann G, Möller HJ, Hegerl U (2002) P300 subcomponents in obsessive-compulsive disorder. J Psychiatr Res 36: 399–406.
  57. Mayberg HS (1997) Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci 9: 471–481.
  58. McClure EB, Monk CS, Nelson EE, Parrish JM, Adler A, Blair RJ Fromm S, Charney DS, Leibenluft E, Ernst M, Pine DS (2007) Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Arch Gen Psychiatry 64: 97–106.
  59. Mendlowicz MV, Stein MB (2000) Quality of life in individuals with anxiety disorders. Am J Psychiatry. 157: 669–682.
  60. Milliery M, Bouvard M, Aupetit J, Cottraux J (2000) Sustained attention in patients with obsessive-compulsive disorder: a controlled study. Psychiatry Res 96: 199–209.
  61. Miyata A, Matsunaga H, Kiriike N, Iwasaki Y, Takei Y, Yamagami S (1998) Event-related potentials in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci 52: 513–518.
  62. Monk CS, Telzer EH, Mogg K, Bradley BP, Mai X, Louro HM, Chen G, McClure-Tone EB, Ernst M, Pine DS (2008) Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry 65: 568–576.
  63. Morault PM, Bourgeois M, Laville J, Bensch C, Paty J (1997) Psychophysiological and clinical value of event-related potentials in obsessive-compulsive disorder. Biol Psychiatry 42: 46–56.
  64. Mulert C, Pogarell O, Juckel G, Rujescu D, Giegling I, Rupp D, Mavrogiorgiou P, Bussfeld P, Gallinat J, Möller HJ, Hegerl U (2004) The neural basis of the P300 potential. Focus on the time-course of the underlying cortical generators. Eur Arch Psychiatry Clin Neurosci 254: 190–198.
  65. Nitschke JB, Sarinopoulos I, Oathes DJ, Johnstone T, Whalen PJ, Davidson RJ, Kalin NH (2009) Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry 166: 302–310.
  66. Nuwer MR, Comi G, Emerson R, Fuglsang-Frederiksen A, Guérit JM, Hinrichs H, Ikeda A, Luccas FJC, Rappelsberger P (1999) IFCN standards for digital recording of clinical EEG. In: Recommendations for the Practice of Clinical Neurophysiology: Guidelines of the International Federation of Clinical Neurophysiology (EEG Suppl. 52) (Deuschl G, Eisen A, Eds). Elsevier Science, Amsterdam, Holland. p. 11–14.
  67. Oathes DJ, Patenaude B, Schatzberg AF, Etkin A (2015) Neurobiological signatures of anxiety and depression in resting-state functional magnetic resonance imaging. Biol Psychiatry 77(4): 385–93.
  68. Pacheco-Unguetti AP, Acosta A, Callejas A, Lupiáñez J (2010) Attention and anxiety: different attentional functioning under state and trait anxiety. Psychol Sci 21: 298–304.
  69. Pacheco-Unguetti AP, Acosta A, Marqués E, Lupiáñez J (2011) Alterations of the attentional networks in patients with anxiety disorders. J Anxiety Disord. 25: 888–895.
  70. Papageorgiou C, Rabavilas A, Liappas I, Stefanis (2003) Do obsessive-compulsive patients and abstinent heroin addicts share a common psychophysiological mechanism. Neuropsychobiology 47: 1–11.
  71. Parnowski T, Jernajczyk W (1977) Inwentarz depresji Becka w ocenie nastroju osób zdrowych i chorych na choroby afektywne (ocena pilotażowa) (in Polish). Psychiatr Pol 11: 417–425.
  72. Pascual-Marqui RD (1999) Review of methods for solving the EEG inverse problem. International Journal of Bioelectromagnetism 1: 75–86.
  73. Pascual-Marqui RD (2002) Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details. Methods Find Exp Clin Pharmacol 24 Suppl D: 5–12.
  74. Pascual-Marqui RD, Esslen M, Kochi K, Lehmann D (2002) Functional imaging with low resolution brain electromagnetic tomography (LORETA): review. Methods Find Exp Clin Pharmacol 24C: 91–95.
  75. Pascual-Marqui RD, Michel CM, Lehmann D (1994) Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. Int J Psychophysiol 18: 49–65.
  76. Phelps EA, Delgado MR, Nearing KI, LeDoux JE (2004) Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43: 897–905.
  77. Pigache R (1976) Comparison of scoring methods for tests of attention including an Error Index for use with schizophrenic patients. Percept Mot Skills 42: 243–253.
  78. inninti NR, Madison H, Musser E, Rissmiller D (2003) MINI International Neuropsychiatric Schedule: clinical utility and patient acceptance. Eur Psychiatry 18: 361–364.
  79. Pizzagalli D, Lehmann D, Koenig T, Gerard M, Pascual-Marqui RD (2000) Face-elicited ERPs and affective attitude: Brain electric microstate and tomography analyses. Clin Neurophysiol 11: 521–531.
  80. Polich J (2007) Updating P300: an integrative theory of P3a and P3b. Clin Neurophysiol 118: 2128–2148.
  81. Pourtois G, Grandjean D, Sander D, Vuilleumier P (2004) Electrophysiological correlates of rapid spatial orienting towards fearful faces. Cereb Cortex 14: 619–633.
  82. Savage CR, Weilburg JB, Duffy FH, Baer L, Shera DM, Jenike MA (1994) Low-level sensory processing in obsessive-compulsive disorder: an evoked potential study. Biol Psychiatry 35: 247–252.
  83. Saxena S, Rauch SL (2000) Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am 23: 563–586.
  84. Schunck T, Erb G, Mathis A, Gilles C, Namer IJ, Hode Y. Demaziere A, Luthringer R, Macher JP (2006) Functional magnetic resonance imaging characterization of CCK-4-induced panic attack and subsequent anticipatory anxiety. Neuroimage 31: 1197–1208.
  85. Schupp HT, Ohman A, Junghöfer M, Weike AI, Stockburger J, Hamm AO (2004) The facilitated processing of threatening faces: an ERP analysis. Emotion 4: 189–200.
  86. Servan-Schreiber D, Perlstein WM, Cohen JD, Mintun M (1998) Selective pharmacological activation of limbic structures in human volunteers: a positron emission tomography study. J Neuropsychiatry Clin Neurosci 10: 148–159.
  87. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59: 22–33.
  88. Shin LM, Liberzon I (2010) The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 35: 169–191.
  89. Smit DJ, Posthuma D, Boomsma DI, De Geus EJ (2007) Heritability of anterior and posterior visual N1. Int J Psychophysiol 66: 196–204.
  90. Smoller JW, Pollack MH, Wassertheil-Smoller S, Jackson RD, Oberman A, Wong ND, Sheps D (2007) Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women’s Health Initiative Observational Study. Arch Gen Psychiatry 64: 1153–1160.
  91. Stanford MS, Vasterling JJ, Mathias CW, Constans JI, Houston RJ (2001) Impact of threat relevance on P3 event-related potentials in combat-related post-traumatic stress disorder. Psychiatry Res 102: 125–137.
  92. Straube T, Kolassa IT, Glauer M, Mentzel HJ, Miltner WH (2004a) Effect of task conditions on brain responses to threatening faces in social phobics: an event-related functional magnetic resonance imaging study. Biol Psychiatry 56: 921–930.
  93. Straube T, Mentzel HJ, Glauer M, Miltner WH (2004b) Brain activation to phobia-related words in phobic subjects. Neurosci Lett 372: 204–208.
  94. Straube T, Preissler S, Lipka J, Hewig J, Mentzel HJ, Miltner WH (2010) Neural representation of anxiety and personality during exposure to anxiety-provoking and neutral scenes from scary movies. Hum Brain Mapp 31: 36–47
  95. Strik WK, Fallgatter AJ, Brandeis D, Pascual-Marqui RD (1998) Three-dimensional tomography of event-related potentials during response inhibition: evidence for phasic frontal lobe activation. Electroencephalogr Clin Neurophysiol 108: 406–413.
  96. Sullivan GM, Dębiec J, Bush DEA, Lyons DM, Ledoux JE (2009) The neurobiology of fear and anxiety: contributions of animal models to current understanding. In: Neurobiology of Mental Illness (Charney DS, Nestler EJ, Eds) (3rd ed.). Oxford University Press, New York, USA. p. 603–626.
  97. Szelenberger W, Piotrowski T, Dąbrowska AJ (2005) Increased prefrontal event-related current density after sleep deprivation. Acta Neurobiol Exp (Wars) 65: 19–28.
  98. Tambs K, Czajkowsky N, Røysamb E, Neale MC, Reichborn-Kjennerud T, Aggen SH, Harris JR, Ørstavik RE, Kendler KS (2009) Structure of genetic and environmental risk factors for dimensional representations of DSM‑IV anxiety disorders. Br J Psychiatry 195: 301–307.
  99. Taylor MJ (2002) Non-spatial attentional effects on P1. Clin Neurophysiol 113: 1903–1908.
  100. Tiplady B (1988) A continuous attention test for the assessment of the acute behavioral effects of drugs. Psychopharmacol Bull 24: 213–216.
  101. Towey J, Bruder G, Hollander E, Friedman D, Erhan H, Liebowitz M, Sutton S (1990) Endogenous event-related potentials in obsessive-compulsive disorder. Biol Psychiatry 28: 92–98.
  102. Turan T, Esel E, Karaaslan F, Basturk M, Oguz A, Yabanoglu I (2002) Auditory event-related potentials in panic and generalised anxiety disorders. Prog Neuropsychopharmacol Biol Psychiatry 26: 123–126.
  103. Vingerhoets G, Santens P, Van Laere K, Lahorte P, Dierckx RA, De Reuck J (2001) Regional brain activity during different paradigms of mental rotation in healthy volunteers: a positron emission tomography study. Neuroimage 13: 381–391.
  104. Vingerhoets G, Santens P, Van Laere K, Lahorte P, Dierckx RA, De Reuck J (2001) Regional brain activity during different paradigms of mental rotation in healthy volunteers: a positron emission tomography study. Neuroimage 13: 381–391.
  105. Wessa M, Jatzko A, Flor H (2006) Retrieval and emotional processing of traumatic memories in posttraumatic stress disorder: peripheral and central correlates. Neuropsychologia 44: 1683–1696.
  106. Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jönsson B, Olesen J, Allgulander C, Alonso J, Faravelli C, Fratiglioni L, Jennum P, Lieb R, Maercker A, van Os J, Preisig M, Salvador-Carulla L, Simon R, Steinhausen HC (2011) The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 21: 655–679.
  107. Wright CI, Martis B, McMullin K, Shin LM, Rauch SL (2003) Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia. Biol Psychiatry 54: 1067–1076.

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