FACTORS RESPONSIBLE FOR THE DEVELOPMENT OF LYME CARDITIS

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Postępy Mikrobiologii - Advancements of Microbiology

Polish Society of Microbiologists

Subject: Microbiology

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ISSN: 0079-4252
eISSN: 2545-3149

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VOLUME 56 , ISSUE 1 (April 2017) > List of articles

FACTORS RESPONSIBLE FOR THE DEVELOPMENT OF LYME CARDITIS

Tomasz Chmielewski * / Stanisława Tylewska-Wierzbanowska

Keywords : Borrelia burgdorferi, Lyme carditis, patomechanizm,   Borrelia burgdorferi, Lyme carditis, patho-mechanism

Citation Information : Postępy Mikrobiologii - Advancements of Microbiology. Volume 56, Issue 1, Pages 100-105, DOI: https://doi.org/10.21307/PM-2017.56.1.100

License : (CC BY-NC-ND 4.0)

Published Online: 21-May-2019

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ABSTRACT

Borrelia burgdorferi sensu lato spirochetes are unique in many aspects. They are the etiological agents of Lyme borreliosis, meta-zoonotic, tick-borne disease of mammals, including humans. Ixodes spp. ticks are the vector. With the exception of erythema chronicum migrant (EM), manifestations of the disease may vary depending on the genospecies of Borrelia burgdorferi sensu lato. One of the symptoms is Lyme carditis. To date, the causative factors and the mechanisms of pathogenesis have not been well-described.
Borrelia burgdorferi spirochetes are considered as one of the most invasive mammalian pathogen. They are able to move through the skin, as well as break into and out of blood vessels, easily crossing the blood-brain barrier. Genes encoding various motility forms are bound with chemotaxis signaling system which leads and coordinates motion functions. The attachment of bacteria to host cells or extracellular matrix may promote colonization and disease development. Lyme disease spirochetes encode several surface proteins including decorin binding adhesion (DbpA), which varies among strains contributing to strain-specific differences in tissue tropism. The strains demonstrating the greatest decorin-binding activity promote the greatest colonization of heart and cause the most severe carditis. Moreover, the manifestation of Lyme carditis in certain hosts may be a result of an autoimmunological reaction due to molecular mimicry between B. burgdorferi and host self-components. In mammals, infection with B. burgdorferi induces the development of antibodies which may cross-react with myosin and neural tissue.

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1. Alaedini A., Latov N.: Antibodies against OspA epitopes of Borrelia burgdorferi cross-react with neural tissue. J. Neuroimmunol. 159, 192–195 (2005)
2. Antonara S., Ristow L., Coburn J.: Adhesion mechanisms of Borrelia burgdorferi. Adv. Exp. Med. Biol. 715, 35–49 (2011)
3. Chmielewski T., Tylewska-Wierzbanowska S.: Interactions between Borrelia burgdorferi and mouse fibroblasts. Pol. J. Microbiol. 59, 157–160 (2010)
4. Coburn J., Cugini C.: Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin alphavbeta3. Proc. Natl. Acad. Sci. USA, 100, 7301–7306 (2003)
5. Coburn J., Leong J., Chaconas G.: Illuminating the roles of the Borrelia burgdorferi adhesins. Trends. Microbiol. 21, 372–379 (2013)
6. Cox J., Krajden M.: Cardiovascular manifestations of Lyme disease. Am. Heart J. 122, 1449–1455 (1991)
7. Harman M. W., Dunham-Ems S.M., Caimano M.J., Belperron A.A., Bockenstedt L.K., Fu H.C., Radolf J.D., Wolgenmuth C.W.: The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue. Proc. Natl. Acad. Sci. USA, 109, 3059–3064 (2009)
8. Kandolf R: Myokarditis-Diagnostik. Dtsch. Med. Wschr. 136, 829–835 (2011)
9. Kraiczy P., Skerka C., Brade V., Zipfel P.F.: Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi. Infect. Immun. 69, 7800–7809 (2001)
10. Kubánek M., Šramko M., Berenová D., Hulínská D., Hrbáčková H., Malušková J., Lodererová A., Málek I., Kautzner J.: Detection of Borrelia burgdorferi sensu lato in endomyocardial biopsy specimens in individuals with recent-onset dilated cardiomyopathy. Eur. J. Heart. Fail. 14, 588–596 (2012)
11. Kühl U., Schultheiss H.P.: Myocarditis: early biopsy allows for tailored regenerative treatment. Dtsch. Arztebl. Int. 109, 361–368 (2012)
12. Lelovas P., Dontas I., Bassiakou E.., Xanthos T.: Cardiac implications of Lyme disease, diagnosis and therapeutic approach. Int. J. Kardiol. 129, 15–21 (2008)
13. Lin Y.-P., Benoit V., Yang X., Martinez-Herranz R., Pal U., Leong J.M.: Strain-specific variation of the decorin-binding adhesion DbpA influence the tissue tropism of the Lyme disease spirochetes. PLOS Pathogens, 10, 1–14 (2014)
14. Moriarty T.J., Norman M.U., Colarusso P., Bankhead T., Kubes P., Chaconas G.: Real-time high resolution 3D imaging of the Lyme disease spirochete adhering to and escaping from the vasculature of a living host. PLOS Pathogens, 4, 1–13 (2008)
15. Motalabed M. A., Liu J., Wooten R.M.: Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease. Curr. Opin. Microbiol. 28, 106–113 (2015)
16. Palecek T., Kuchynka P., Hulinska D., Schramlova J., Hrbackova H., Vitkova I., Simek S., Horak J., Louch W.E., Linhart A.: Presence of Borrelia burgdorferi in endomyocardial biopsies in patients with new-onset unexplained dilated cardiomyopathy. Med. Microbiol. Immunol. 199, 139–143 (2010)
17. Raveche E.S., Schutzer S.E., Fernandes H., Bateman H., McCarthy B.A., Nickell S.P., Cunningham M.W.: Evidence of Borrelia autoimmunity-induced component of Lyme carditis and arthritis. J. Clin. Microbiol. 43, 850–856 (2005)
18. Scheffold N., Hercommer B., Kandolf R., May A.E.: Lyme carditis-diagnosis, treatment and prognosis. Dtsch. Arztebl. Int. 12, 202–208 (2015)
19. Stanek G., Klein J., Bittner R., Glogar D.: Isolation of Borrelia burgdorferi from the myocardium of a patient with longstanding cardiomyopathy. N. Engl. J. Med. 322, 249–252 (1990)
20. Steere, A.C., Batsford W.P., Weinberg M., Alexander J., Berger H.J., Wolfson S., Malawista S.E.: Lyme carditis: cardiac abnormalities of Lyme disease. Ann. Intern. Med. 93, 8–16 (1980)
21. Strle F., Stanek G.: Clinical manifestations and diagnosis of Lyme borreliosis. Curr. Probl. Dermatol. 37, 51–110 (2009)
22. Sultan S.Z, Manne A., Stewart P.E., Ross P.A., Charon N.W., Motaleb M.A.: Motility is crucial for infectious life cycle of Borrelia burgdorferi. Infect. Immun. 81, 2012–2021 (2013)
23. Sultan S.Z, Sekar P., Ahao X., Manne A., Liu J., Wooten M.R., Motaleb M.A.: Motor rotaton is essential for formation of the periplasmic flagellar ribbon, cellular morhology, and Borrelia burgdorferi persistance within Ixodes scapularis tick and murine hosts. Infec. Immun. 83, 1765–1777 (2015)
24. Tylewska-Wierzbanowska S., Chmielewski T.: Borelioza (choroba z Lyme) (w) Choroby zakaźne i pasożytnicze-epidemiologia
i profilaktyka, red. A. Baumann-Popczyk, M. Sadkowska-Todys, A. Zieliński, α-medica press, Bielsko-Biała, 2014, s. 38–44
25. van der Linde M.R.: Lyme carditis: clinical characteristics of 105 cases. Scand. J. Infect. Dis. 77 (Suppl III), 81–84 (1991)
26. Wolgemuth C.W.: Flagellar motility of the pathogenic spirochetes. Sem. Cell Dev. Biol. 46, 104–112 (2015)

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