BACTERIAL MOONLIGHTING PROTEINS

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Postępy Mikrobiologii - Advancements of Microbiology

Polish Society of Microbiologists

Subject: Microbiology

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VOLUME 56 , ISSUE 2 (April 2017) > List of articles

BACTERIAL MOONLIGHTING PROTEINS

Jagoda Płaczkiewicz *

Keywords : bakteryjna patogeneza, białka wielofunkcyjne, enzymy, bacterial pathogenesis, moonlighting proteins, enzymes

Citation Information : Postępy Mikrobiologii - Advancements of Microbiology. Volume 56, Issue 2, Pages 226-232, DOI: https://doi.org/10.21307/PM-2017.56.2.226

License : (CC BY-NC-ND 4.0)

Published Online: 22-May-2019

ARTICLE

ABSTRACT

Existence of moonlighting proteins in microorganisms is a known phenomenon, yet still not well understood. Moonlighting proteins have at least two independent biological functions, which must be performed by one polypeptide chain without separation into protein domains. Most of these proteins, beside their role in the cytoplasm, play an important role outside of the cell i.e. they take part in the process of pathogenesis by binding and activating host’s plasminogen. The existence of moonlighting proteins complicates the understanding of pathogenicity and virulence of many common bacteria as well as their role in commensal bacteria. Many of moonlighting proteins occurring in commensal bacteria appear to perform similar functions to proteins discovered in pathogenic bacteria, e.g. binding extracellular matrix. Moonlighting proteins found in bacteria are mostly housekeeping enzymes, especially from the glycolytic pathway, such as enolase, aldolase, dehydrogenase as well as heat-shock proteins and transcriptional factors.

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