GENETIC DIVERSITY OF BOVINE DIARRHEA AND MUCOSAL DISEASE VIRUS

Publications

Share / Export Citation / Email / Print / Text size:

Postępy Mikrobiologii - Advancements of Microbiology

Polish Society of Microbiologists

Subject: Microbiology

GET ALERTS

ISSN: 0079-4252
eISSN: 2545-3149

DESCRIPTION

13
Reader(s)
33
Visit(s)
0
Comment(s)
0
Share(s)

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue / page

Related articles

VOLUME 56 , ISSUE 4 (April 2017) > List of articles

GENETIC DIVERSITY OF BOVINE DIARRHEA AND MUCOSAL DISEASE VIRUS

Paweł Mirosław * / Aleksandra Antos / Mirosław Polak

Keywords : diagnostics, subtypes, bovine viral diarrhea and mucosal disease virus, genetic diversity

Citation Information : Postępy Mikrobiologii - Advancements of Microbiology. Volume 56, Issue 4, Pages 389-394, DOI: https://doi.org/10.21307/PM-2017.56.4.389

License : (CC BY-NC-ND 4.0)

Published Online: 22-May-2019

ARTICLE

ABSTRACT

Bovine viral diarrhea virus (BVDV) is classified as a member of the Pestivirus genus of the Flaviviridae family. BVDV is one of the most important viral pathogens of ruminants worldwide, causing severe economic losses. Infection results in a wide range of clinical manifestations, ranging from mild respiratory disease to fetal death and mucosal disease. The virus particles are small and contain a single-stranded, positive-sense RNA molecule of approximately 12.3 kb with one large open reading frame flanked by two untranslated regions (5’UTR and 3’UTR). The polyprotein is proteolytically cleaved by viral and host proteases resulting in the formation of mature viral proteins. It is well established that BVDV strains show considerable genetic diversity. BVD viruses are classified as two species: BVDV-1 and BVDV-2. Quite recently, a new putative species, BVDV-3, was detected. The viruses exist as one of two biotypes: cytopathic or non-cytopathic, based on their activity in cell cultures. The phylogenetic analysis of the 5’UTR and Npro region has revealed at least 21 distinct subtypes of BVDV-1 and 4 subtypes of BVDV-2. Genetic diversity of BVD viruses has serious clinical implications such as immune evasion, increase of virulence, host range alteration and also affects the efficacy of vaccination programmes and diagnostic methods.

Content not available PDF Share

FIGURES & TABLES

REFERENCES

1. Abe Y.: Genetic and antigenic characterization of bovine viral diarrhea viruses isolated from cattle in Hokkaido, Japan. J. Vet. Med. Sci. 78, 61–70 (2016)

2. Anderson J.P., Daifuku R., Loeb L.A.: Viral error catastrophe by mutagenic nucleosides. Annu. Rev. Microbiol. 58, 183–205 (2004)

3. Bachofen C., Braun U., Hilbe M., Ehrensperger F., Stalder H., Peterhans E.: Clinical appearance and pathology of cattle persistently infected with bovine viral diarrhoea virus of different genetic subgroups. Vet. Microbiol. 141, 258–267 (2010)

4. Bauermann F.V., Flores E.F., Ridpath J.F.: Antigenic relationships between Bovine viral diarrhea virus 1 and 2 and HoBi virus: Possible impacts on diagnosis and control. J. Vet. Diagn. Invest. 24, 253–261 (2012)

5. Bauhofer O., Summerfield A., Sakoda Y., Tratschin J.D., Hofmann M.A., Ruggli N.: Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation. J. Virol. 81, 3087–3096 (2007)

6. Becher P., Orlich M., Thiel H.: Mutations in the 5’ Nontranslated Region of Bovine Viral Diarrhea Virus Result in Altered Growth Characteristics. J. Virol. 74, 7884–7894 (2000)

7. Decaro N., Elia G. i wsp.: Evidence for Circulation of Bovine Viral Diarrhoea Virus Type 2c in Ruminants in Southern Italy. Transbound. Emerg. Dis. DOI: 10.1111/tbed (2016)

8. Domingo E., Holland J.: RNA virus mutations and fitness for survival. Annu. Rev. Microbiol. 51, 151–178 (1997)

9. Fulton R.W., Ridpath J.F., Confer A.W., Saliki J.T., Burge L.J., Payton M. E.: Bovine viral diarrhoea virus antigenic diversity: impact on disease and vaccination programmes. Biologicals, 31, 89–95 (2003)

10. Fulton R.W., Ridpath J.F., Saliki J.T., Briggs R.E., Confer A.W., Burge L.J., Purdy C.W., Loan R.W., Duff G.C., Payton M.E.: Bovine viral diarrhea virus (BVDV) 1b: predominant BVDV subtype in calves with respiratory disease. Can. J. Vet. Res. 66, 181–190 (2002)

11. Gethmann J., Homeier T., Holsteg M., Schirrmeier H., Saβerath M., Hoffmann B., Beer M., Conraths F.J.: BVD-2 outbreak leads to high losses in cattle farms in Western Germany. Heliyon, 1, e00019 (2015)

12. Giammarioli M., Ceglie L., Rossi E., Bazzucchi M., Casciari C., Petrini S., De Mia G.M.: Increased genetic diversity of BVDV-1: recent Findings and implications thereof. Virus Genes, 50, 147–151 (2015)

13. Giangaspero M., Harasawa R., Weber L., Belloli A.: Genoepidemiological Evaluation of Bovine viral diarrhea virus 2 Species Based on Secondary Structures in the 5’ Untranslated Region. J. Vet. Med. Sci. 70, 571–580 (2008)

14. Gottipati K., Acholi S., Ruggli N., Choi K.: Autocatalytic activity and substrate specificity of the pestivirus N-terminal protease Npro. Virology, 452–453, 303–309 (2014)

15. Gripshover E.M., Givens M.D., Ridpath J.F., Brock K.V., Whitley E.M., Sartin E.A.: Variation in Erns viral glycoprotein associated with failure of immunohistochemistry and commercial antigen capture ELISA to detect a field strain of bovine viral diarrhea virus. Vet. Microbiol. 125, 11–21 (2007)

16. Hausmann, Roman-Sosa G., Thiel H., Rümenapf T.: Classical Swine Fever Virus Glycoprotein Erns Is an Endoribonuclease with an Unusual Base Specificity. J. Virol. 78, 5507–5512 (2004)

17. Hornberg A., Fernandez S.R., Vogl C., Vilcek S., Matt M., Fink M., Kofer J., Schopf K.: Genetic diversity of pestivirus isolates in cattle from Western Austria. Vet. Microbiol. 135, 205–213 (2009)

18. Houe H.: Economic impact of BVDV infection in dairies. Biologicals, 31, 137–143 (2003)

19. Isken O., Grassmann C.W., Yu H., Behrens S.E.: Complex signals in the genomic 3’ nontranslated region of bovine viral diarrhea virus coordinate translation and replication of the viral RNA. RNA, 10, 1637–1652 (2004)

20. Isken O., Langerwisch U., Schönherr R., Lamp B., Schröder K., Duden R., Rümenapf T., Tautz N.: Functional Characterization of Bovine Viral Diarrhea Virus Nonstructural Protein 5A by Reverse Genetic Analysis and Live Cell Imaging. J. Virol. 88, 82–98 (2014)

21. Jenckel M., Hoper D., Schirrmeier H., Reimann I., Goller K., Beer M.: Mixed Triple: allied viruses in unique isolates of recent highly virulent type 2 bovine viral diarrhea virus (BVDV-2) detected by deep sequencing. J. Virol. 88, 6983–6992 (2014)

22. Jones L.R., Zandomeni R.O., Weber E.L.: A long distance RT-PCR able to amplify the Pestivirus genome. J. Virol. Methods. 134, 197–204 (2006)

23. King A.M.Q., Adams M.J., Carstens E.B., Lefkowitz E.J.: Virus Taxonomy. Ninth Report of the International Committee on Taxonomy of Viruses. Elsevier Academic Press, Amsterdam, 2012

24. Klemens O., Dubrau D., Tautz N.: Characterization of the Determinants of NS2-3-Independent Virion Morphogenesis of Pestiviruses. J. Virol. 89, 11668–11680 (2015)

25. Kuta A., Polak M.P., Larska M., Żmudziński J.F.: Predominance of bovine viral diarrhea virus 1b and 1d subtypes during eight years of survey in Poland. Vet. Microbiol. 166, 639–644 (2013)

26. Kuta A., Polak M.P., Larska M., Żmudziński J.F.: Genetic typing of bovine viral diarrhea virus (BVDV) by restriction fragment length polymorphism (RFLP) and identification of a new subtype in Poland. B. Vet. I. Pulawy. 59, 19–22 (2015)

27. Lang Y., Gao S., Du J., Shao J., Cong G., Lin T., Zhao F., Liu L., Chang H.: Polymorphic genetic characterization of E2 gene of bovine viral diarrhea virus in China. Vet. Microbiol. 174, 554–559 (2014)

28. Largo E., Gladue D., Huarte N., Borca M., Nieva J.: Pore-forming activity of pestivirus p7 in a minimal model system supports genus-specific viroporin function. Antivir. Res. 101, 30–36 (2014)

29. Letellier C., Kerkhofs P.: Real-time PCR for simultaneous detection and genotyping of bovine viral diarrhea virus. J. Virol. Methods. 114, 21–27 (2003)

30. Liu L., Xia H., Belak S., Baule C.: A TaqMan real time RT-PCR assay for selective detection of atypical bovine pestivirus in clinical and biological products. J. Virol. Methods. 154, 82–85 (2008)

31. Liu L., Xia H., Wahlberg N., Belák S., Baule C.: Phylogeny, classification and evolutionary insight into pestiviruses. Virology, 385, 351–357 (2009)

32. Mishra N., Pattnaik B., Vilcek S., Patil S.S., Jain P., Swamy N., Bhatia S., Pradhan H.K.: Genetic typing of bovine viral diarrhoea virus isolates from India. Vet. Microbiol. 104, 207–212 (2004)

33. Mishra N., Rajukumar K., Vilcek S., Tiwari A., Satav J.S., Dubey S.C.: Molecular characterization of bovine viral diarrhea virus type 2 isolate originating from a native Indian sheep (Oviesaries). Vet. Microbiol. 130, 88–98 (2008)

34. Nagai M., Hayashi M., Sugita S., Sakoda Y., Mori M., Murakami T., Ozawa T., Yamada N., Akashi H.: Phylogenetic analysis of bovine viral diarrhea viruses using five different genetic regions. Virus Res. 99, 103–113 (2004)

35. Neill J.D.: Molecular biology of bovine viral diarrhea virus. Biologicals, 41, 2–7 (2013)

36. Oem J., Chung J., Roh I., Kim H., Bae Y., Lee K., Jin Y., Lee O.: Characterization and phylogenetic analysis of Bovine viral diarrhea virus in brain tissues from nonambulatory (downer) cattle in Korea. J. Vet. Invest. 22, 518–523 (2010)

37. Ostachuk A.: Bovine viral diarrhea virus structural protein E2 as a complement regulatory protein. Arch. Virol. 161, 1769–1782 (2016)

38. Paletto S., Zuccon F., Pitti M., Gobbi E., Marco L., Caramelli M., Masoero L., Acutis P.L.: Detection and phylogenetic analysis of an atypical pestivirus, strain IZSPLV_To. Res. Vet. Sci. 92, 147–150 (2012)

39. Pecora A., Malacari D.A., Ridpath J.F., Aguirreburualde M.S. Perez, Combessies G., Odeón A.C., Romera S.A., Golemba M.D., Widgorovitz A.: First finding of genetic and antigenic diversity in 1b-BVDV isolates from Argentina. Res. Vet. Sci. 96, 204–212 (2013)

40. Polak M. P., Kuta A., Rybałtowski W., Rola J., Larska M., Żmudziński J. F.: First report of bovine Viral diarrhoea virus-2 infection in cattle in Poland. Vet. J. 202, 643–645 (2014)

41. Quadros V.L., Mayer S.V., Vogel F.S.F., Welblen R., Brum M.C.S., Arenhart S., Flores E.F.: A search for RNA insertions and NS3 gene duplication in the genome of cytopathic isolates of bovine viral diarrhea virus. Braz. J. Med. Biol. Res. 39, 935–944 (2006)

42. Ridpath J.F.: BVDV genotypes and biotypes: practical implications for diagnosis and control. Biologicals, 31, 127–131 (2003)

43. Ridpath J.F.: Practical significance of heterogeneity among BVDV strains: Impact of biotype and genotype on U.S. control programs. Prev. Vet. Med. 72, 17–30 (2005)

44. Ridpath J.F., Fulton R.W., Kirkland P.D., Neill J.D.: Prevalence and antigenic differences observed between Bovine viral diarrhea virus subgenotypes isolated from cattle in Australia and feedlots in the southwestern United States. J. Vet. Invest. 22, 184–191 (2010)

45. Sanjuán R., Domingo-Calap P.: Mechanisms of viral mutation. Cell Mol. Sci. 73, 4433–4448 (2016)

46. Schirrmeier H.: Three years of mandatory BVDV control in Germany – lessons to be learned. Proceedings of the 28th World Buiatrics Congress WBC, Australia, 2014

47. Silveira S., Weber M.N., Mosena A.C.S., Silva M.S., Streck A.F., Pescador C.A., Flores E.F., Weiblen R., Driemeier D., Ridpath J.F., Canal C.W.: Genetic Diversity of Brazilian Bovine Pestiviruses Detected Between 1995 and 2014. Transbound. Emerg. Dis. doi: 10.1111/tbed (2015)

48. Stahl K., Beer M., Schirrmeier H., Hoffman B., Belak S., Alenius S.: Atypical ‘HoBi’-like pestiviruses-Recent findings and implications thereof. Vet. Microbiol. 142, 90–93 (2010)

49. Stalder H.P., Meier P., Pfaffen G., Wageck-Canal C., Rufenacht J., Schaller P., Bachofen C., Marti S., Vogt H.R., Peterhans E.: Genetic heterogeneity of pestiviruses of ruminants in Switzerland. Prev. Vet. Med. 72, 37–41 (2005)

50. Strong R., Errington J., Cook R., Ross-Smith N., Wakeley P., Steinbach F.: Increased phylogenetic diversity of bovine viral diarrhoea virus type 1 isolates in England and Wales since 2001. Vet. Microbiol. 162, 315–320 (2013)

51. Tautz N., Meyers G., Thiel H.J.: Pathogenesis of mucosal disease, a deadly disease of cattle caused by a pestivirus. Clin. Diagn. Virol. 10, 121–127 (1998)

52. Tews B.A., Meyers G.: The pestivirus glycoprotein Erns is anchored in plane in the membrane via an amphipathic helix. J. Biol. Chem. 282, 32730–32741 (2007)

53. Toplak I., Sandvik T., Barlic-Maganja D., Grom J., Paton D.J.: Genetic typing of bovine viral diarrhoea virus: most Slovenian iso-
lates are of genotypes 1d and 1f. Vet. Microbiol. 99, 175–185 (2004)

54. Uttenhal A., Stadejek T., Nylin B.: Genetic diversity of bovine viral diarrhoea viruses (BVDV) in Denmark during a 10-year eradication period. Acta Path. Micro. Im. 113, 536–541 (2005)

55. Vilcek S., Durkovic B., Kolesarova M., Greiser-Wilke I., Paton D.: Genetic diversity of international bovine viral diarrhoea virus (BVDV) isolates: identification of a new BVDV-1 genetic group. Vet. Res. 35, 609–615 (2004)

56. Weiskircher E., Aligo J., Ning G., Konan K.V.: Bovine viral diarrhea virus NS4B protein is an integral membrane protein associated with Golgi markers and rearranged host membranes. Virol. J. 3, 185 (2009)

57. Worobey M., Holmes E.: Evolutionary aspects of recombination in RNA viruses. J. Gen. Virol. 80, 2535–2543 (1999)

EXTRA FILES

COMMENTS