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VOLUME 57 , ISSUE 1 (June 2018) > List of articles

FRANCISELLA TULARENSIS – REVIEW 

Piotr Cieślik / Józef Knap / Agata Bielawska-Drózd *

Keywords : characteristic of etiological agent, diagnostic methods, F. tularensis, treatment, vaccination

Citation Information : Postępy Mikrobiologii - Advancements of Microbiology. Volume 57, Issue 1, Pages 58-67, DOI: https://doi.org/10.21307/PM-2018.57.1.058

License : (CC BY-NC-ND 4.0)

Published Online: 20-May-2019

ARTICLE

ABSTRACT

In the early twentieth century, Francisella tularensis was identified as a pathogenic agent of tularaemia, one of the most dangerous zoonoses. Based on its biochemical properties, infective dose and geographical location, four subspecies have been distinguished within the species F. tularensis: the highly infectious F. tularensis subsp. tularensis (type A) occurring mainly in the United States of America, F. tularensis subsp. holarctica (type B) mainly in Europe, F. tularensis subsp. mediasiatica isolated mostly in Asia and F. tularensis subsp. novicida, non-pathogenic to humans. Due to its ability to infect and variable forms of the disease, the etiological agent of tularaemia is classified by the CDC (Centers for Disease Control and Prevention, USA) as a biological warfare agent with a high danger potential (group A). The majority of data describing incidence of tularaemia in Poland is based on serological tests. However, real-time PCR method and MST analysis of F. tularensis highly variable intergenic regions may be also applicable to detection, differentiation and determination of genetic variation among F. tularensis strains. In addition, the above methods could be successfully used in molecular characterization of tularaemia strains from humans and animals isolated in screening research, and during epizootic and epidemic outbreaks.

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