DANGER THEORY AND DAMAGE - ASSOCIATEDMOLECULAR PATTERN

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VOLUME 57 , ISSUE 4 (April 2018) > List of articles

DANGER THEORY AND DAMAGE - ASSOCIATEDMOLECULAR PATTERN

Agata Poniewierska-Baran / Beata Tokarz-Deptuła * / Wiesław Deptuła

Keywords : danger theory, danger factors, DAMP

Citation Information : Postępy Mikrobiologii - Advancements of Microbiology. Volume 57, Issue 4, Pages 328-337, DOI: https://doi.org/10.21307/PM-2018.57.4.328

License : (CC BY-NC-ND 4.0)

Published Online: 24-May-2019

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ABSTRACT

The immune system of mammals has developed many mechanisms to effectively defend itself against foreign factors, including pathogens. In 1994, Polly Matzinger published a theory of danger, a new view in immunology, describing the response of the immune system to danger, caused by trauma and/or presence of pathogens. This theory sheds a different view on the current belief, that the immune system distinguishes between own (self) and foreign (non-self) structures and reacts only to non-self factors. According to the danger theory, the immune system has the ability to verify “safe” and “dangerous” factors, thus explaining immune reactions caused by tissue damage, referred to as “sterile inflammation”, but also occurring during the infection. It is believed that the fundamental elements in danger theory are dangerous molecules i.e. – damage-associated molecular patterns (DAMPs), which are released from damaged or dead tissue and cells. They are also present in physiological conditions and give analogous immune response to these induced by self/ non-self factors.

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