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North American Journal of Medicine and Science

American Chinese Medical Exchange Society

Acmes Publications Inc

Subject: Medicine

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ISSN: 1946-9357
eISSN: 2156-2342

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Concomitant 1q42.13-q44 Duplication and 14q32.33 Deletion: A Case Report and Review of Literature
Screening Genetic Alterations of Biomarkers BRAF, ROS-1, and HER2 by Immunohistochemistry in Ovarian Carcinomas for Targeted Therapy

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Volume 11 (2018)
Volume 10 (2017)
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VOLUME 10 , ISSUE 1 (January 2017) - List of articles

The Prevalence of alpha-Thalassemia in Anemic US Veterans without Nutritional Deficiency or Abnormal Hemoglobin HPLC Pattern

Jessenia Guerrero/ Oliver Cai/ Shahida Ahmed/ Donghong Cai

Alpha-thalassemia is one of the most common hemoglobin genetic abnormalities. The primary defect is the reduced or absent production of the alpha globin chains, which underlines 4 clinical conditions: 1) alpha+-thalassemia (loss of one alpha globin), 2) alpha0-thalassemia (loss of 2 alpha globins), 3) HbH disease (loss of 3 alpha globins), and 4) Hb Bart hydrops fetalis syndrome (loss of all alpha globins). Among the anemic US veteran patients, one subpopulation defies extensive workup and remai(..)

DOI: 10.7156/najms.2017.1001001

Published Online: 25-April-2017

Evaluation of the Vysis IntelliFISH Hybridization Buffer and Vysis IntelliFISH Universal FFPE Pretreatment and Wash Kit in FISH Assays

Jiawei Zhao/ Chengwen Li/ Jing Xiao/ Yingchun Zheng/ Kejing Tang/ Shenghua Chen/ Kun Ru

Standard fluorescence in-situ hybridization (FISH) technique requires a hybridization time of 12 hours or greater, thus amounting to a turn-around time (TAT) of 24 hours or greater for result reporting. To improve the TAT for the FISH tests, a new Vysis IntelliFISH Hybridization Buffer has been recently developed by Abbott Molecular. It was evaluated in 20 pairs of matched bone marrow samples and 10 pairs of matched formalin-fixed lymphoma tissue samples against the standard Vysis LSI/WCP Hybrid(..)

DOI: 10.7156/najms.2017.1001005

Published Online: 29-May-2017

Malignant Pleural Effusion, an Unusual Presentation of Metastatic Adenoid Cystic Carcinoma: A Case Report and Review of the Literature

Ayesha Arshad

Adenoid cystic carcinoma (ACC) is an uncommon malignant neoplasm of the major and minor salivary glands that is known to have a long clinical course, behaving in an insidious and indolent fashion with multiple recurrences preceding distant metastasis. Reported here is a case of a patient presenting with shortness of breath and recurrent pleural effusion. Exfoliated ACC cells were observed on cytological evaluation, a rare occurrence. Mediastinal lymph node involvement was also confirmed on cytol(..)

DOI: 10.7156/najms.2017.1001009

Published Online: 29-May-2017

Composite Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Cell Lymphoma with 17p Deletion: A Case Study

Hanan Armanious/ Jean Deschênes/ Wei-Feng Dong/ Iyare Izevbaye

Here we describe a case of a composite mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small cell lymphocytic lymphoma (CLL/SLL) with 17p deletion in the MCL. The patient presented with 3 years of progressive lymphocytosis. Cervical lymph node biopsy showed morphologic features of nodular MCL and internodular CLL/SLL, two populations of CD5+ cells by flow cytometry, a t(11;14) translocation with a deletion in chromosome 11 by FISH, and biclonal IGH gene rearrangement. In the peripher(..)

DOI: 10.7156/najms.2017.1001014

Published Online: 29-May-2017

Polyostotic Fibrous Dysplasia Mimicking Metastatic Disease Radiographically: A Case Report and Literature Review

David Gay/ Joey Philip/ Shahida Ahmed/ Jin Choe/ Donghong Cai

Fibrous dysplasia is a benign intramedullary lesion characterized by an excessive proliferation of cellular fibrous tissue intermixed with irregular trabeculae. It involves any of the bones presenting as monostotic, polyostotic, or panostotic lesion. It is caused by mutation in the GNAS1 gene (20q13.2, encoding a G-protein) resulting in inhibition of intrinsic GTPase activity of Gs alpha protein. The timing of mutation in the developmental course determines the extent of the disease, in which an(..)

DOI: 10.7156/najms.2017.1001021

Published Online: 29-May-2017

Small Bowel Ischemic Necrosis Secondary to Idiopathic Intimal and Medial Hyperplasia of Mesenteric Vessels: A Case Report

Meenal Sharma/ Zhongren Zhou

Small bowel ischemic necrosis secondary to idiopathic intimal and medial hyperplasia of mesenteric small vessels is rare. The mesenteric vascular diseases were recently classified as two vascular diseases: fibromuscular dysplasia (FMD) of artery and mesenteric arteriovenous dysplasia/vasculopathy (MAVD/V). FMD usually involves medium size mesenteric arteries in younger individuals. In contrast, MAVD/V tends to affect multiple small mesenteric arteries and veins without vascular lesions in other (..)

DOI: 10.7156/najms.2017.1001025

Published Online: 29-May-2017

ZAP70 Related Severe Combined Immunodeficiency Initially Diagnosed as Incomplete (Atypical) Kawasaki Disease

Andrew Alexander/ Monika Pilichowska

ZAP70-related severe combined immunodeficiency (SCID) is a defect of the immune system characterized by absent or extremely low CD8+ T-cells and abnormal T-cell receptor signaling. This form of SCID is relatively rare with about 20 cases currently described in the literature and typically presents in infancy with recurrent opportunistic infections, failure to thrive, and gastrointestinal symptoms. This report describes a case of ZAP70-related SCID that was initially diagnosed as incomplete (atyp(..)

DOI: 10.7156/najms.2017.1001029

Published Online: 29-May-2017

A Rare Case of Myelodysplastic Syndrome with Ring Sideroblasts, SF3B1 and TET2 Mutations in a Patient with Beta Thalassemia Trait

Jeffrey Ahlstedt/ Yanhua Wang/ Yanan Fang

Concurrent myelodysplastic syndrome (MDS) and β-thalassemia trait is rare. We reported a case of a 59-year-old man with a known history of β-thalassemia (presumed to be β-thalassemia intermedia) presenting with progressive anemia and worsening fatigue. β-globin mutation analysis revealed a heterozygous mutation in the beta-globin gene, compatible with β-thalassemia trait. Bone marrow biopsy showed erythroid hyperplasia and erythroid dysplasia with increased ring sideroblasts (>15%). Additionally(..)

DOI: 10.7156/najms.2017.1001032

Published Online: 29-May-2017

Gliomatosis Peritonei: Report of Two Cases and Literature Review

Jialing Huang/ Robbie Atienza/ Rajiv Pulinthanathu

Gliomatosis peritonei (GP) is a rare condition characterized by intraabdominal (peritoneal, nodal and omental) implants of glial tissue. GP is believed to be commonly associated with immature ovarian teratoma and possesses favorable prognosis. However, the origin of GP is controversial and its clinical outcomes vary. Here we reported 2 cases of GP arising in mature and immature ovarian teratoma, respectively. Recent literature is also reviewed.  

DOI: 10.7156/najms.2017.1001036

Published Online: 29-May-2017

A Case of CD5-/Cyclin D1+/SOX11- Mantle Cell Lymphoma with an Aberrant Immunophenotype and Indolent Clinical Course

Lei Zhang/ Nan Zhang

Mantle cell lymphoma (MCL) is a clinically aggressive B-cell lymphoma associated with 11q13 translocation, which leads to cyclin D1 overexpression in almost all cases. Although CD5 expression is characteristic in MCL, rare CD5 negative cases with variable expression of CD10 and CD23 have been reported. Over the recent years, a subgroup of MCL with a relatively indolent clinical course started to be recognized. Herein, we report a case of CD5-/Cyclin D1+/SOX11- MCL in a 75-year-old female with di(..)

DOI: 10.7156/najms.2017.1001040

Published Online: 29-May-2017

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