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Acta Neurobiologiae Experimentalis

Nencki Institute of Experimental Biology

Polish Neuroscience Society

Subject: Behavioral Sciences , Biomedical Sciences & Nutrition , Life Sciences , Medicine , Neurosciences


ISSN: 0065-1400
eISSN: 1689-0035



Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
Neuroprotective effects of lipopolysaccharide and naltrexone co-preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat
Differences in spatio-temporal distribution of the visual P3b event-related potential between young men and women
Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor

VOLUME 76 , ISSUE 1 (March 2016) - List of articles

Lithium – therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms

Miroslava Vosahlikova/ Petr Svoboda

Mood disorders are relatively common serious human diseases for which there is often no ideal pharmacotherapy. Basic characteristic of these diseases is affective disorder shifting the mood of the patient to depression (together with anxiety or not) or towards to euphoria. Available drugs are usually divided into two groups – mood stabilizers, which are used primarily to treat bipolar disorder,and antidepressants for the treatment of unipolar depression. Lithium is still recommended as the first(..)

DOI: 10.21307/ane-2017-001

Published Online: 25-July-2017

Effectors of large-conductance calcium-activated potassium channel modulate glutamate excitotoxicity
in organotypic hippocampal slice cultures

Marta Piwońska/ Adam Szewczyk/ Ulrich H. Schröder/ Klaus G. Reymann/ Piotr Bednarczyk

Mitochondria have been suggested as a potential target for cytoprotective strategies. It has been shown that increased K+ uptake mediate by mitochondrial ATP-regulated potassium channels (mitoKATP channel) or large-conductance Ca2+-activated potassium channels (mitoBKCa channel) may provide protection in different models of cell death. Since recent findings demonstrated the presence of BKCa channels in neuronal mitochondria, the goal of the present study was to test the potential neuroprotective(..)

DOI: 10.21307/ane-2017-002

Published Online: 14-August-2017

Chronotype and sleep quality as a subphenotype in association studies of clock genes in mood disorders

Monika Dmitrzak-Węglarz/ Joanna Pawlak/ Monika Wiłkość/ Izabela Miechowicz/ Małgorzata Maciukiewicz/ Wanda Ciarkowska/ Dorota Zaremba/ Joanna Hauser

Genetic background and clinical picture of mood disorders (MD) are complex and may depend on many genes and their potential interactions as well as environmental factors. Therefore, clinical variations, or endophenotypes, were suggested for association studies. The aim of the study was to investigate association between the chronotype (CH) and quality of sleep characteristics with polymorphisms CLOCK, ARNTL, TIMELESS and PER3 genes in MD. We included a total sample of 111 inpatients and 126 heal(..)

DOI: 10.21307/ane-2017-003

Published Online: 25-July-2017

BDNF gene polymorphisms and haplotypes in relation to cognitive performance in Polish healthy subjects

Monika Wiłkość/ Agnieszka Szałkowska/ Maria Skibińska/ Ludmiła Zając-Lamparska/ Małgorzata Maciukiewicz/ Aleksander Araszkiewicz

The brain derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in the cell survival, axonal and dendritic growth, and synaptic plasticity. BDNF gene polymorphisms, functional Val66Met mainly, were shown to influence human brain structure and cognition. The aim of the study was to assess the relationship between twelve BDNF gene variants and their haplotypes and cognitive performance measured using the Wisconsin Card Sorting Test (WCST), the Trail Making Test (TMT), t(..)

DOI: 10.21307/ane-2017-004

Published Online: 25-July-2017

Cerebellar cortex development in the weaver condition presents regional and age-dependent abnormalities without differences in Purkinje cells neurogenesis

Joaquín Martí/ María C. Santa-Cruz/ José P. Hervás/ Shirley A. Bayer/ Sandra Villegas

Ataxias are neurological disorders associated with the degeneration of Purkinje cells (PCs). Homozygous weaver mice (wv/wv) have been proposed as a model for hereditary cerebellar ataxia because they present motor abnormalities and PC loss. To ascertain the physiopathology of the weaver condition, the development of the cerebellar cortex lobes was examined at postnatal day (P): P8, P20 and P90. Three approaches were used: 1) quantitative determination of several cerebellar features; 2) qualitati(..)

DOI: 10.21307/ane-2017-005

Published Online: 06-October-2017

Testosterone metabolism: a possible biological underpinning of non-verbal IQ in intellectually gifted girls

Jaroslava Durdiaková/ Peter Celec/ Jolana Laznibatová/ Gabriel Minárik/ Daniela Ostatníková

The extraordinary giftedness is apparently a unique manifestation of a mutual interconnection between genes and environment. One of the possible etiological factors of intellectual giftedness is testosterone which is believed to affect the brain organization and function. The aim of our study was to analyze associations between 2D:4D digit ratio (a proxy of prenatal testosterone) and/or salivary testosterone levels with non-verbal IQ in intellectually gifted girls. Fifty-one girls with an age ra(..)

DOI: 10.21307/ane-2017-006

Published Online: 25-July-2017

EEG source activity during processing of neutral stimuli in subjects with anxiety disorders

Bartłomiej Gmaj/ Piotr Januszko/ Jan Kamiński/ Ewa Drozdowicz/ Maciej Kopera/ Dorota Wołyńczyk-Gmaj/ Waldemar Szelenberger/ Marcin Wojnar

Anxiety disorders are a social problem due to their prevalence and consequences. It is crucial to explore the influence of anxiety on cognitive processes. In this study we recorded EEG activity from 73 subjects (35 patients, 38 controls, matched for age and education)during performance of the Continuous Attention Task. We used low resolution electromagnetic tomography (LORETA) for evaluation of mechanisms of impaired cognitive performance in anxiety disorders. Analysis showed that patients with (..)

DOI: 10.21307/ane-2017-007

Published Online: 25-July-2017

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