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Acta Neurobiologiae Experimentalis

Nencki Institute of Experimental Biology

Polish Neuroscience Society

Subject: Behavioral Sciences , Biomedical Sciences & Nutrition , Life Sciences , Medicine , Neurosciences


ISSN: 0065-1400
eISSN: 1689-0035



Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
Neuroprotective effects of lipopolysaccharide and naltrexone co-preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat
Differences in spatio-temporal distribution of the visual P3b event-related potential between young men and women
Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor

VOLUME 77 , ISSUE 1 (March 2017) - List of articles

Effects of epidural compression on stellate neurons and thalamocortical afferent fibers in the rat primary somatosensory cortex

Tzu-Yin Yeh/ Guo-Fang Tseng/ Chi-Yu Tseng/ Yung-Hsin Huang/ Pei-Hsin Liu

A number of neurological disorders such as epidural hematoma can cause compression of cerebral cortex. We here tested the hypothesis that sustained compression of primary somatosensory cortex may affect stellate neurons and thalamocortical afferent (TCA) fibers. A rat model with barrel cortex subjected to bead epidural compression was used. Golgi-Cox staining analyses showed the shrinkage of dendritic arbors and the stripping of dendritic spines of stellate neurons for at least 3 months post-les(..)

DOI: 10.21307/ane-2017-032

Published Online: 06-February-2018

Energy-dense diet triggers changes in gut microbiota, reorganization of gut-brain vagal communication and increases body fat accumulation

Alexandra C. Vaughn/ Erin M. Cooper/ Patricia M. DiLorenzo/ Levi J. O’Loughlin/ Michael E. Konkel/ James H. Peters/ Andras Hajnal/ Tanusree Sen/ Sun Hye Lee/ Claire B. de La Serre/ Krzysztof Czaja

Obesity is associated with consumption of energy-dense diets and development of systemic inflammation. Gut microbiota play a role in energy harvest and inflammation and can influence the change from lean to obese phenotypes. The nucleus of the solitary tract (NTS) is a brain target for gastrointestinal signals modulating satiety and alterations in gut-brain vagal pathway may promote overeating and obesity. Therefore, we tested the hypothesis that high-fat diet-induced changes in gut microbiota a(..)

DOI: 10.21307/ane-2017-033

Published Online: 06-February-2018

Impact of recurrent hypoglycemic stress on hindbrain A2 nerve cell energy metabolism and catecholamine biosynthesis: modulation by estradiol

Pratistha Tamrakar/ Karen P. Briski

It is unclear if habituation of hindbrain A2 metabolo-sensory neurons to recurrent insulin-induced hypoglycemia (RIIH) correlates with estradiol-dependent adjustments in energy metabolism that favor positive energy balance. Laser-microdissected A2 cells from estradiol- or oil-implanted ovariectomized female rats were analyzed by Western blot to assess effects of three prior daily insulin injections on basal and hypoglycemic patterns of catecholamine biosynthetic enzyme dopamine-beta-hydroxylase (..)

DOI: 10.21307/ane-2017-034

Published Online: 06-February-2018

Effects of Cornus mas L. and Morus rubra L. extracts on penicillin-induced epileptiform activity: an electrophysiological and biochemical study#

Filiz Tubaş/ Sedat Per/ Abdulkadir Taşdemir/ Ayşe Kaçar Bayram/ Mehmet Yıldırım/ Aydın Uzun/ Recep Saraymen/ Hakan Gümüş/ Ferhan Elmalı/ Hüseyin Per

Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin-induced epilept(..)

DOI: 10.21307/ane-2017-035

Published Online: 06-February-2018

Nicorandil attenuates neuronal mitochondrial dysfunction and oxidative stress associated with murine model of vascular calcification

Sriram Ravindran/ Krithika Swaminathan/ Abhinaya Ramesh/ Gino A. Kurian

Evidences suggest that the presence of chronic kidney disease (CKD) is associated with cerebrovascular diseases related cognitive decline in dialysis patients. As mitochondrial dysfunction is implicated in neurodegenerative disorders, we hypothesized that changes in brain mitochondria occur due to vascular calcification induced by renal failure and the opening of the mitochondrial potassium channel using nicorandil may prevent its dysfunction. Brain tissues from rats with vascular calcification (..)

DOI: 10.21307/ane-2017-036

Published Online: 06-February-2018

Comparison of the influence of two models of mild stress on hippocampal brain-derived neurotrophin factor (BDNF) immunoreactivity in old age rats

Ewa Badowska-Szalewska/ Beata Ludkiewicz/ Rafał Krawczyk/ Natalia Melka/ Janusz Moryś

The way hippocampal neurons function during stress in old age (critical times of life) is dependent on brain derived neurotrophin factor (BDNF). This study examined the influence of acute and chronic forced swim (FS) or high-light open field (HL-OF) stimulation on the density of BDNF immunoreactive (ir) neurons in the hippocampal pyramidal layers of CA1, CA2, CA3 regions and the granular layer of dentate gyrus (DG) in old (postnatal day 720; P720) Wistar Han rats. Our data showed that in compari(..)

DOI: 10.21307/ane-2017-037

Published Online: 06-February-2018

Further pharmacological characterization of eltoprazine: focus on its anxiolytic, anorexic, and adverse-effect potential

Andreas Gravius/ Andrzej Dekundy/ Anita Vanaga/ Lutz Franke/ Wojciech Danysz

Eltoprazine, a drug that had previously been developed for aggression, has recently been investigated for L-DOPA-induced dyskinesia in animal models of Parkinson´s disease (PD) and in dyskinetic PD patients. Much less is known about effects of eltoprazine in other therapeutic indications. Indeed, the pharmacological profile of eltoprazine might suggest its effects on anxiety and food intake, but also adverse effect potential, which is the focus of the present study. Given for 2 weeks either as i(..)

DOI: 10.21307/ane-2017-038

Published Online: 06-February-2018

Effect of combined administration of aripiprazole and fluoxetine on cognitive functions in female rats exposed to ethyl alcohol

Krzysztof Kus/ Piotr Ratajczak/ Natasza Czaja/ Tomasz Zaprutko/ Elżbieta Nowakowska

Alcoholism is a chronic and recurrent disease. The studies on ethyl alcohol show a progressive deterioration of cognitive functions (motor hyperactivity, operating memory). The aim of the study was to establish whether combined single and chronic administration of aripiprazole (ARI) and fluoxetine (FLU) affects animal locomotor activity or modifies spatial memory functions in female rats exposed to ethyl alcohol. Female Wistar rats were studied in the Morris Water Maze (MWM) and locomotor activi(..)

DOI: 10.21307/ane-2017-039

Published Online: 06-February-2018

Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats

Olusiji Akinrinmade/ Sylvester Omoruyi/ Daneel Dietrich/ Okobi Ekpo

Stroke is the second leading cause of death worldwide, affecting about 240 people a day in South Africa and leaving survivors with residual disabilities. At the moment, there is no clinically approved neuroprotective product for stroke but the consumption of plant polyphenols has been suggested to offer some protection against stroke. In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in ad(..)

DOI: 10.21307/ane-2017-040

Published Online: 06-February-2018

Nigrostriatal interaction in the aging brain: new therapeutic target for Parkinson’s disease

Janusz W. Błaszczyk

Parkinson’s disease (PD) is a progressive neurodegenerative disorder of unclear etiology and pathogenesis. Research results gathered to date support the hypothesis that the motor symptoms of the disease result from the gradual loss of midbrain dopamine neurons residing in the substantia nigra pars compacta (SNpc). Recent discoveries, however, significantly expand this knowledge indicating that the primary source of the PD pathogenesis may be located both in the SNpc as well as in the GABAergic s(..)

DOI: 10.21307/ane-2017-041

Published Online: 06-February-2018

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