Professor Jerzy Vetulani (1936–2017)

Ryszard Przewłocki

DOI: 10.21307/ane-2017-042

4^th International Seminar on Behavioral Methods

DOI: 10.21307/ane-2017-052

Dichlorodiphenyltrichloroethane (DDT) induced extracellular vesicle formation: a potential role in organochlorine increased risk of Parkinson’s disease

Mario Rossi/ Marco Scarselli/ Irene Fasciani/ Roberto Maggio/ Franco Giorgi

A number of studies have demonstrated that rural living and exposure to pesticides such as dichlorodiphenyltrichloroethane (DDT) highly increase the chances of developing Parkinson’s disease. In a previous work, we have found that DDT leads to the formation of vesicular buds that are released from the cells upon fusion of an intermediate endocytic compartment with the plasma membrane. Since extracellular vesicles like exosomes have been implicated in the development of neurodegenerative diseases(..)

DOI: 10.21307/ane-2017-043

Published Online: 06-February-2018

Functional organization of the human amygdala in appetitive learning

Emilia Kolada/ Krzysztof Bielski/ Marcel Falkiewicz/ Iwona Szatkowska

The amygdala is a small subcortical structure located bilaterally in medial temporal lobes. It is a key region for emotional processes and some forms of associative learning. In particular, the role of the amygdala in processing of negative emotions and aversive learning has been shown in numerous studies. However, involvement of this structure in processing of positive affect and appetitive learning is not fully understood. Previous experiments in animals are not consistent. While some authors (..)

DOI: 10.21307/ane-2017-044

Published Online: 06-February-2018

Interaction between urethane and cannabinoid CB1 receptor agonist and antagonist in penicillin-induced epileptiform activity

Gokhan Arslan/ Sabiha Kubra Alici/ Mustafa Ayyildiz/ Erdal Agar

Previous experimental studies have shown that various anesthetics alter the effects of cannabinoid agonists and antagonists on the cardiac response to different stimuli. Since no data have shown an interaction between urethane and cannabinoid signaling in epilepsy, we examined the suitability of urethane with regard to testing the effects of a cannabinoid CB1 receptor agonist and an antagonist on penicillin-induced epileptiform activity in rats. Permanent screw electrodes for electrocorticograph(..)

DOI: 10.21307/ane-2017-045

Published Online: 29-September-2017

Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test

Katarina Savić Vujović/ Sonja Vučković/ Dolika Vasović/ Branislava Medić/ Nick Knežević/ Milica Prostran

Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone. Antinociceptive activity was assessed by the formalin test in male Wistar rats (200–250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related behavior(..)

DOI: 10.21307/ane-2017-046

Published Online: 06-February-2018

Narcolepsy type 1 and hypersomnia associated with a psychiatric disorder show different slow wave activity dynamics

Ewa Walacik-Ufnal/ Anna Justyna Piotrowska/ Dorota Wołyńczyk-Gmaj/ Piotr Januszko/ Bartłomiej Gmaj/ Marcin Ufnal/ Marek Kabat/ Marcin Wojnar

The aim of the study was to compare electrophysiological parameters of night sleep in narcolepsy type 1 and hypersomnia associated with a psychiatric disorder. Forty-four patients: 15 with narcolepsy type 1, 14 with hypersomnia associated with a psychiatric disorder and 15 age- and sex-matched controls participated in the study. The study subjects filled in the Athens Insomnia Scale (AIS) and the Beck Depression Inventory (BDI). The severity of daytime sleepiness was quantified subjectively usin(..)

DOI: 10.21307/ane-2017-047

Published Online: 29-September-2017

An effect of continuous contextual filling in the filled-space illusion

Aleksandr Bulatov/ Natalija Bulatova/ Tadas Surkys/ Lina Mickienė

In the filled-space (or Oppel-Kundt) illusion, the filled part of the stimulus for most observers appears longer in comparison with the empty one. In the first two experimental series of the present study, we investigated the illusory effect as a function of continuous filling (by a shaft-line segment) of the reference spatial interval of the three-dot stimulus. It was demonstrated that for the fixed length of the reference interval, the magnitude of the illusion increases non-linearly with the (..)

DOI: 10.21307/ane-2017-048

Published Online: 06-February-2018

Nonlinear dynamics analysis of the human balance control subjected to physical and sensory perturbations

Mohammed N. Ashtiani/ Mahmood-reza Azghani

Postural control after applying perturbation involves neural and muscular efforts to limit the center of mass (CoM) motion. Linear dynamical approaches may not unveil all complexities of body efforts. This study was aimed at determining two nonlinear dynamics parameters (fractal dimension (FD) and largest Lyapunov exponent (LLE)) in addition to the linear standing metrics of balance in perturbed stance. Sixteen healthy young males were subjected to sudden rotations of the standing platform. The (..)

DOI: 10.21307/ane-2017-049

Published Online: 24-July-2017

Potential role of dopamine transporter in behavioral flexibility

Anita Cybulska-Klosowicz/ Julia Dabrowska/ Sebastian Niedzielec/ Renata Zakrzewska/ Aleksandra Rozycka

Behavioral flexibility is subserved by the prefrontal cortex and the basal ganglia. Orbitofrontal cortex (OFC) and dorsomedial striatum (DMS) form a functional frontocorticostriatal circuit crucial for the mediation of flexibility during reversal learning via dopamine (DA) neurotransmission. The regulatory control in maintaining DA homeostasis and function is provided by the dopamine transporter (DAT), which therefore likely plays a significant role in controlling the influence of DA on cognitiv(..)

DOI: 10.21307/ane-2017-050

Published Online: 06-February-2018

Effect of ethanol on the visual-evoked potential in rat: dynamics of ON and OFF responses

Redas Dulinskas/ Rokas Buisas/ Valentina Vengeliene/ Osvaldas Ruksenas

The effect of acute ethanol administration on the flash visual-evoked potential (VEP) was investigated in numerous studies. However, it is still unclear which brain structures are responsible for the differences observed in stimulus onset (ON) and offset (OFF) responses and how these responses are modulated by ethanol. The aim of our study was to investigate the pattern of ON and OFF responses in the visual system, measured as amplitude and latency of each VEP component following acute administr(..)

DOI: 10.21307/ane-2017-051

Published Online: 06-February-2018