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Acta Neurobiologiae Experimentalis

Nencki Institute of Experimental Biology

Polish Neuroscience Society

Subject: Behavioral Sciences , Biomedical Sciences & Nutrition , Life Sciences , Medicine , Neurosciences

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ISSN: 0065-1400
eISSN: 1689-0035

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FEATURED ARTICLES

Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
Neuroprotective effects of lipopolysaccharide and naltrexone co-preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat
Differences in spatio-temporal distribution of the visual P3b event-related potential between young men and women
Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor

VOLUME 78 , ISSUE 1 (March 2018) - List of articles

A role for the GDAP1 gene in the molecular pathogenesis of Charcot-Marie-Tooth disease

Weronika Rzepnikowska/ Andrzej Kochański

In 2002 a series of mutations in the GDAP1 gene were reported in patients suffering from Charcot-Marie-Tooth disease manifesting as early–onset, progressive distal-muscle wasting and weakness. The molecular etiology of Charcot-Marie-Tooth -GDAP1 disease has been elucidated but its pathogenesis remains unclear, especially given the seemingly contradictory function of the GDAP1 protein. Expression of GDAP1 is observed almost exclusively in neuronal cells, however, the GDAP1 protein is present in m(..)

DOI: 10.21307/ane-2018-002

Published Online: 18-May-2018

Experimental cerebral hemispherectomy in rodent models. A systematic review of current literature

Cezar Octavian Morosanu/ Razvan Lucian Jurca/ Larisa Simonca/ Roxana Flavia Ilies/ Remus Moldovan/ Ioan Stefan Florian/ Gabriela Adriana Filip

Cerebral hemispherectomy is a neurosurgical procedure that involves surgically removing one hemisphere of the brain, used as a therapeutic option in severe cases of intractable epilepsy. Several animal models have contributed to our understanding of the underlying neuromechanisms. The review was based on a PubMed search using the terms “hemispherectomy” and “mouse” or “rat” or “rodent”, with no limitation of year of study or language. We identified a series of elements that were collected and an(..)

DOI: 10.21307/ane-2018-003

Published Online: 18-May-2018

Cerebral hypoperfusion in autism spectrum disorder

Geir Bjørklund/ Janet K. Kern/ Mauricio A. Urbina/ Khaled Saad/ Amira A. El-Houfey/ David A. Geier/ Salvatore Chirumbolo/ Mark R. Geier/ Jyutika A. Mehta/ Jan Aaseth

Cerebral hypoperfusion, or insufficient blood flow in the brain, occurs in many areas of the brain in patients diagnosed with autism spectrum disorder (ASD). Hypoperfusion was demonstrated in the brains of individuals with ASD when compared to normal healthy control brains either using positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The affected areas include, but are not limited to the: prefrontal, frontal, temporal, occipital, and parietal cortices; th(..)

DOI: 10.21307/ane-2018-005

Published Online: 18-May-2018

MeCP2 in central nervous system glial cells: current updates

Kedarlal Sharma/ Juhi Singh/ Emma E. Frost/ Prakash P. Pillai

Methyl-CpG binding protein 2 (MeCP2) is an epigenetic regulator, which preferentially binds to methylated CpG dinucleotides in DNA. MeCP2 mutations have been linked to Rett syndrome, a neurodevelopmental disorder characterized by severe intellectual disability in females. Earlier studies indicated that loss of MeCP2 function in neuronal cells was the sole cause of Rett syndrome. Subsequent studies have linked MeCP2 expression in CNS glial cells to Rett syndrome pathogenesis. In this review, we h(..)

DOI: 10.21307/ane-2018-007

Published Online: 18-May-2018

Possible role of hippocampal GPR55 in spatial learning and memory in rats

Bruno A. Marichal-Cancino/ Alfonso Fajardo-Valdez/ Alejandra E. Ruiz-Contreras/ Mónica Méndez-Díaz/ Oscar Prospéro-García

Endocannabinoids (eCBs) are involved in the hippocampal mechanisms of spatial learning and memory in rats. Although eCBs exert many of their actions on spatial learning and memory via CB1 receptors, the putative cannabinoid receptor GPR55 (expressed in the hippocampus, cortex, forebrain, cerebellum and striatum) seems to be also involved. To investigate the potential role of GPR55 in spatial learning and memory, Wistar rats received bilateral infusions of lysophosphatidylinositol (LPI, GPR55-ago(..)

DOI: 10.21307/ane-2018-001

Published Online: 18-May-2018

Long-term behavioral, histological, biochemical and hematological evaluations of amyloid beta-induced Alzheimer’s disease in rat

Raheleh Kheirbakhsh/ Mahnaz Haddadi/ Ahad Muhammadnejad/ Alireza Abdollahi/ Farshad Shahi/ Behzad Amanpour-Gharaei/ Azadeh Abrahim-Habibi/ Tahereh Barati/ Saeid Amanpour

Alzheimer’s disease (AD) is a mental impairment and neural degeneration which causes progressive loss of memory and cognitive functions. This age-dependent illness is associated with extracellular amyloid plaques accumulation and twisted neurofibrillary tangles. Amyloid plaques are experimentally generated in animal models in order to investigate the disease process. In this study, we followed a rat model of AD for over a year. Wistar rats were divided randomly into two groups as control group ((..)

DOI: 10.21307/ane-2018-004

Published Online: 18-May-2018

Effects of postural and cognitive difficulty levels on the standing of healthy young males on an unstable platform

Shahram Oliaei/ Mohammed N. Ashtiani/ Kamran Azma/ Sandra Saidi/ Mahmood-Reza Azghani

Standing on an unstable platform requires continuous effort of the neuro-musculoskeletal system. The aim of the present study is to evaluate the ability to remain standing on an unstable platform at different levels of postural and cognitive difficulty. Healthy young males stood in the sagittal plane on an unstable platform supported by a pair of springs with modifiable stiffness. The balance test also assessed different levels of vision and cognitive function. Linear and nonlinear metrics of st(..)

DOI: 10.21307/ane-2018-006

Published Online: 18-May-2018

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