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Acta Neurobiologiae Experimentalis

Nencki Institute of Experimental Biology

Polish Neuroscience Society

Subject: Behavioral Sciences , Biomedical Sciences & Nutrition , Life Sciences , Medicine , Neurosciences

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ISSN: 0065-1400
eISSN: 1689-0035

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FEATURED ARTICLES

Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
Neuroprotective effects of lipopolysaccharide and naltrexone co-preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat
Differences in spatio-temporal distribution of the visual P3b event-related potential between young men and women
Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor

VOLUME 78 , ISSUE 3 (September 2018) - List of articles

Role of food-drug interactions in neurological and psychological diseases

Makbule Gezmen-Karadağ/ Elif Çelik/ Fatma Zehra Kadayifçi/ Özge Yeşildemir/ Yasemin Ertaş Öztürk/ Duygu Ağagündüz

Given that foods and nutrients have been shown to influence the pharmacokinetics of drugs, drugs may cause changes in the nutritional status of patients and their response to a given drug. Food-drug interactions are particularly relevant for drugs used to treat neurological and psychological diseases. This review provides an overview of food-drug interaction in the treatment of neurological and psychological diseases. A literature search was carried out by collecting data from different reviews,(..)

DOI: 10.21307/ane-2018-017

Published Online: 10-October-2018

Charcot-Marie-Tooth type 1A drug therapies: role of adenylyl cyclase activity and G-protein coupled receptors in disease pathomechanism

Artur J. Kiepura/ Andrzej Kochański

Charcot-Marie-Tooth type 1A (CMT1A) is a dysmyelinating disease of the peripheral nervous system that results in a slow progressive weakening and wasting of the distal muscles of the upper and lower limbs. Despite extensive research and clinical trials there is still no treatment for CMT1A that results in complete neurological improvement. Recent studies investigating various pharmacological modulators of adenylyl cyclase activity, including ascorbic acid and ligands of G protein-coupled recepto(..)

DOI: 10.21307/ane-2018-018

Published Online: 10-October-2018

The role of DSCAM in the regulation of synaptic plasticity: possible involvement in neuropsychiatric disorders

Katarzyna Stachowicz

Synaptic plasticity simply put, is the activity-dependent modification of the strength or efficacy of synaptic transmission in the network of synapses in the brain. The role of synaptic plasticity in disease is an active area of research. Changes in plasticity translate to the release of neurotransmitters at the synapse and subsequently, the way humans see the world. It is known that neuropsychiatric disorders such as depression, posttraumatic stress disorder (PTSD), and Alzheimer’s disease (AD)(..)

DOI: 10.21307/ane-2018-019

Published Online: 10-October-2018

Hindlimb suspension-induced cell apoptosis in the posterior parietal cortex and lateral geniculate nucleus: corresponding changes in c-Fos protein and the PI3K/Akt signaling pathway

Wei Huang/ Chen Chen/ Xufeng Liu

Recent physiological studies indicate that weightlessness reliably alters ocular structure and function, as well as the ability to process visual-spatial information. The posterior parietal cortex (PPC) and lateral geniculate nucleus (LGN) are two key brain areas implicated in the processing of visual-spatial information. Here, we used the modified tail-suspension rat model to simulate the physiological effects of microgravity. Rats were divided into four groups, which exposed to the simulated m(..)

DOI: 10.21307/ane-2018-020

Published Online: 10-October-2018

Effects of PINK1 mutation on synapses and behavior in the brain of Drosophila melanogaster

Bartosz Doktór/ Milena Damulewicz/ Wojciech Krzeptowski/ Barbara Bednarczyk/ Elżbieta Pyza

Mutations in the PINK1 gene are responsible for typical symptoms of Parkinson’s disease. Using Drosophila melanogaster mutant PINK1B9 and after PINK1 silencing with RNAi using transgenic lines, we observed defects in synapses and behavior. The lack or reduced expression of PINK1 prolonged sleep during the day (nap) and decreased the total locomotor activity during 24 h, in addition to a decrease in climbing ability and a reduced lifespan. In the brain, PINK1 mutants had a lower level of Bruchpil(..)

DOI: 10.21307/ane-2018-021

Published Online: 10-October-2018

Effects of extensive amygdaloid lesions on conditioned taste aversion in rats

Andrés Molero-Chamizo

The role of the amygdala in the acquisition of conditioned taste aversion (CTA) is unclear. The lesion studies that have explored specific nuclei of the amygdala point to a probable involvement of the basolateral amygdala, but it remains unclear whether the function of the amygdala in CTA is limited to the activity of the basolateral amygdala. In the current study, extensive bilateral lesions of the amygdala were performed in Wistar rats to explore if the destruction of the amygdala affects the (..)

DOI: 10.21307/ane-2018-022

Published Online: 10-October-2018

Afferent projections of the subthalamic nucleus in the rat: emphasis on bilateral and interhemispheric connections

Safiye Çavdar/ Merve Özgür/ Yusuf Özgür Çakmak/ Yasemin Kuvvet/ Sıla Kezban Kunt/ Gökay Sağlam

The subthalamic nucleus (STN) is important for normal movement as well as in movement disorders. The STN is a target nuclei in patients with advanced Parkinson’s disease (PD). Deep brain stimulation (DBS) is a standard surgical treatment for PD. Although DBS results in a significant reduction in motor disability, several negative side effects have been reported. Thus, to understand the side effects of DBS the connection of the STN should be well known. Therefore, the present study aims to re-exa(..)

DOI: 10.21307/ane-2018-023

Published Online: 10-October-2018

Testosterone enhancement during pregnancy influences social coping and gene expression of oxytocin and vasopressin in the brain of adult rats

Zuzana Dzirbíková/ Alžbeta Talarovičová/ Peter Štefánik/ Lucia Olexová/ Lucia Kršková

Steroid hormones are important mediators of prenatal maternal effects and play an important role in fetal programming. The aim of our study was to investigate how testosterone enhancement during pregnancy influences neurobehavioral aspects of social coping of rat offspring in adulthood. Pregnant rat dams were exposed to depot form of testosterone during the last third of pregnancy (i.e., beginning on the 14th day of pregnancy). Their adult offspring were later tested in a social interaction test(..)

DOI: 10.21307/ane-2018-024

Published Online: 10-October-2018

The use of MR-less MNI based neuronavigation for 10 Hz rTMS depression therapy: electrophysiological and clinical implications

Vladas Valiulis/ Giedrius Gerulskis/ Kastytis Dapšys/ Karolina Valavičiūtė/ Aldona Šiurkutė/ Valentinas Mačiulis

Repetitive transcranial magnetic stimulation (rTMS) is a popular and effective treatment for drug resistant depression. However, there is considerable variability in clinical outcomes, in previous studies and between patients. Because of high requirements for the use of fMRI based neuronavigation, many practitioners of rTMS still choose to use a standard 5 cm rule for rTMS coil placement which leads to large variations in which brain regions are being stimulated. We decided to test the possibili(..)

DOI: 10.21307/ane-2018-025

Published Online: 10-October-2018

MMP-3 deficiency does not influence the length and number of CA1 dendrites of hippocampus of adult mice

Daria Nowak/ Lies De Groef/ Lieve Moons/ Jerzy W. Mozrzymas

Over the past two decades, metalloproteinases (MMPs), including MMP-2, MMP-3, and MMP-9, have been implicated as important players in mechanisms underlying various forms of neuroplasticity. In particular, MMP-3 was found to be involved in both cognitive functions and in plasticity phenomena, but the underlying molecular mechanisms remain largely elusive. In general, it is believed that functional plasticity of neurons is associated with morphological alterations. Interestingly, MMP-9, in additio(..)

DOI: 10.21307/ane-2018-026

Published Online: 10-October-2018

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