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Acta Neurobiologiae Experimentalis

Nencki Institute of Experimental Biology

Polish Neuroscience Society

Subject: Behavioral Sciences , Biomedical Sciences & Nutrition , Life Sciences , Medicine , Neurosciences

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ISSN: 0065-1400
eISSN: 1689-0035

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FEATURED ARTICLES

Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
Neuroprotective effects of lipopolysaccharide and naltrexone co-preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat
Differences in spatio-temporal distribution of the visual P3b event-related potential between young men and women
Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor

VOLUME 78 , ISSUE 4 (December 2018) - List of articles

c-Fos and neuronal plasticity: the aftermath of Kaczmarek’s theory

Jacek Jaworski/ Katarzyna Kalita/ Ewelina Knapska

The development of molecular biology methods in the early 1980s led to a better understanding of the role of transcription factors in mammalian cells. The discovery that some transcription factors are critically important for cells to switch between different functional states was fundamental for modern molecular neurobiology. In the 1980s Leszek Kaczmarek proposed that, analogically to the cell cycle or to cell differentiation, long-term synaptic plasticity, learning, and memory should also req(..)

DOI: 10.21307/ane-2018-027

Published Online: 15-January-2019

Lin28 overexpression inhibits neurite outgrowth of primary cortical neurons in vitro

Mohammad Iqbal Hossain Bhuiyan/ Seong Yun Kim/ Kyung-Ok Cho

Lin28 has been shown to promote proliferation of progenitors and survival of neurons during cortical neurogenesis. However, the role of Lin28 in the terminal maturation of neurons remains obscured. In this study, we investigated the developmental impact of Lin28 overexpression on neurite outgrowth. Lin28 expression was upregulated by in utero electroporation at E14.5. Two days later, electroporated cortices were dissociated for culturing primary cortical neurons. We found that Lin28 overexpressi(..)

DOI: 10.21307/ane-2018-028

Published Online: 15-January-2019

A relationship between brainstem auditory evoked potential and vagal control of heart rate in adult women

Ariany G. Silva/ Ana Claúdia F. Frizzo/ Eduardo F. B. Chagas/ David M. Garner/ Rodrigo D. Raimundo/ Luiz Vinicius de Alcantara Sousa/ Vitor E. Valenti

Numerous studies have investigated the connection between autonomic control of heart rate (HR) and auditory stimulus. Yet, the literature lacks evidence of a close association between auditory brainstem processing and HR autonomic control. We aimed to evaluate and verify the relationship between auditory brainstem response (ABR) and HR variability (HRV) in healthy women. Forty-six healthy female subjects, between the ages of 18 and 30 years old participated in the study. They were subjected to a(..)

DOI: 10.21307/ane-2018-029

Published Online: 15-January-2019

Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline

Anna Furgała/ Robert Sałat/ Kinga Sałat

Oxaliplatin is a third-generation, platinum-based antitumor drug used to treat colorectal cancer. Since its main adverse effect is neuropathic pain resulting from chemotherapy-induced peripheral neuropathy (CIPN), this drug is used to study the neurobiology of CIPN in rodents and to search for analgesics that could attenuate neuropathic pain symptoms – cold and tactile allodynia that develop in most of the oxaliplatin-treated subjects. In this research, testing across various temperatures, we as(..)

DOI: 10.21307/ane-2018-030

Published Online: 15-January-2019

Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer’s disease

Yasemin Bilgic/ Enver Ahmet Demir/ Nilufer Bilgic/ Hatice Dogan/ Okan Tutuk/ Cemil Tumer

Polyphenols and omega-3 fatty acids are thought to have beneficial effects in Alzheimer’s disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum-induced Alzheimer’s disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was establ(..)

DOI: 10.21307/ane-2018-031

Published Online: 15-January-2019

Dopamine D2 receptor blockade differentially affects the light-adapted turtle and frog electroretinogram

Elka Popova/ Petia Kupenova

The effects of dopamine D2-class receptor blockade by sulpiride on the electroretinographic (ERG) b-wave (ON response) and d-wave (OFF response) were investigated in light-adapted turtle (Trachemys scripta elegans) and frog (Rana ridibunda) eyecups. For turtle ERG, sulpiride (240 μM) produced an amplitude increase of the band d-waves, while the 40 μM and 120 μM of sulpiride were ineffective. Alternatively, for frog ERG, a well-developed and dose-dependent band d-wave amplitude decrease was obtai(..)

DOI: 10.21307/ane-2018-032

Published Online: 15-January-2019

Calcium release from intracellular stores is involved in mitochondria depolarization after lowering extracellular pH in rat brain synaptosomes

Tatsiana G. Dubouskaya/ Sviatlana V. Hrynevich/ Tatsiana V. Waseem/ Sergei V. Fedorovich

In the brain, pH can be lowered in both healthy and disease states. Previously, we showed that moderate extracellular acidification (down to pHo 7.0), but not intracellular acidification, leads to mitochondrial depolarization in synaptosomes. This indicates that the plasma membranes of neuronal presynaptic endings have proton receptors that can induce mitochondrial dysfunction when activated. In the present paper we attempt to identify this hypothetical receptor. First, we have demonstrated that(..)

DOI: 10.21307/ane-2018-033

Published Online: 15-January-2019

Neurological improvement in patients with chronic spinal cord injury treated with leuprolide acetate, an agonist of GnRH

José Luis Quintanar/ Carmen Díaz-Galindo/ Denisse Calderón-Vallejo/ Irma Hernández-Jasso/ Froylán Rojas/ Daniel Medina-Aguiñaga/ Carlos Olvera-Sandoval

It has been reported that gonadotropin-releasing hormone (GnRH), and its analogue leuprolide acetate (LA), have neurotrophic properties; particularly in the regeneration of injured spinal cord in animal models and in the case of a patient with spinal cord injury (SCI). The aim of this study was to establish whether treatment with LA improves sensitivity, motor activity and independence in patients with chronic SCI. Patients were treated LA once a month for six months. They were evaluated at the (..)

DOI: 10.21307/ane-2018-034

Published Online: 15-January-2019

Anti-inflammatory compound curcumin and mesenchymal stem cells in the treatment of spinal cord injury in rats

Jiri Ruzicka/ Lucia Machova Urdzikova/ Anna Kloudova/ Anubhav G. Amin/ Jana Vallova/ Sarka Kubinova/ Meic H. Schmidt/ Meena Jhanwar-Uniyal/ Pavla Jendelova

Spinal cord injury leads to a robust inflammatory response that is an unfavorable environment for stem cell implantation. In this study, we evaluated the effect of combined therapy of curcumin and mesenchymal stem cells (MSC) on behavioral recovery and tissue sparing, glial scar formation, axonal sprouting and inflammatory responses in a rat experimental model of spinal cord injury (SCI). Balloon-induced compression lesion was performed at thoracic (Th8-9) spinal level. Out of the four groups st(..)

DOI: 10.21307/ane-2018-035

Published Online: 15-January-2019

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