VOLUME 80 , ISSUE 1 (April 2020) - List of articles

Sort by

Neuroprotective effect of poly(lactic-co-glycolic acid) nanoparticle-bound brain-derived neurotrophic factor in a permanent middle cerebral artery occlusion model of ischemia in rats

Siti Norsyafika Kamarudin/ Igor Iezhitsa/ Minaketan Tripathy/ Renad Alyautdin/ Nafeeza Mohd Ismail

Poly (lactide-co-glycolide) (PLGA) nanoparticles (NPs) are biodegradable carriers that participate in the transport of neuroprotective drugs across the blood brain barrier (BBB). Targeted brain-derived neurotrophic factor (BDNF) delivery across the BBB could provide neuroprotection in brain injury. We tested the neuroprotective effect of PLGA nanoparticle-bound BDNF in a permanent middle cerebral artery occlusion (pMCAO) model of ischemia in rats. Sprague-Dawley rats were subjected to pMCAO. Fou(..)

DOI: 10.21307/ane-2020-001

Local field potential power spectra and locomotor activity following treatment with pseudoephedrine in mice

Nusaib Sa-ih/ Chayaporn Reakkamnuan/ Nifareeda Samerphob/ Dania Cheaha/ Saree Niyomdecha/ Ekkasit Kumarnsit

The efficacy of pseudoephedrine (PSE) as a nasal decongestant has been well-demonstrated; however, PSE is strictly prescribed as a control substance due to its controversial psychostimulant effects. Although standard stimulatory drugs increase exploratory behavior and stimulate the dopamine system, the exact effects of PSE on locomotion and electrical activity in the striatum have not been determined. This study aimed to examine and compare the locomotor activities, local field potential (LFP) a(..)

DOI: 10.21307/ane-2020-002

C60 fullerenes increase the intensity of rotational movements in non-anesthetized hemiparkinsonic rats

Andriy V. Maznychenko/ Olena P. Mankivska/ Inna V. Sokolowska (Vereshchaka)/ Bohdan S. Kopyak/ Tomasz Tomiak/ Nataliya V. Bulgakova/ Olga O. Gonchar/ Yuriy I. Prylutskyy/ Uwe Ritter/ Iryna V. Mishchenko/ Alexander I. Kostyukov

The effect of C60 fullerene aqueous colloid solution (C60FAS) on the intensity of long-lasting (persisting for one hour) rotational movements in non-anesthetized rats was investigated. For this purpose, an experimental hemiparkinsonic animal model was used in the study. Rotational movements in hemiparkinsonic animals were initiated by the intraperitoneal administration of the dopamine receptor agonist apomorphine. It was shown that a preliminary injection of C60FAS (a substance with powerful ant(..)

DOI: 10.21307/ane-2020-003

Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells

Zahra Baharvand/ Mohammad Nabiuni/ Mohammad Tahmaseb/ Elaheh Amini/ Sareh Pandamooz

Following nerve tissue damage, various events, such as inflammatory responses, microglial activation, endoplasmic reticulum stress, and apoptosis, can occur, which all lead to cell death, prevent axonal growth, and cause axonal circumvolution. So far, several researchers have tended to adopt strategies to reduce the harmful conditions associated with neurological disorders, and stem-cell-based therapy is one of those promising strategies. Epidermal neural crest stem cells (EPI-NCSCs) are a type (..)

DOI: 10.21307/ane-2020-004

Moderate exercise prevents the cell atrophy caused by hypothyroidism in rats

Carmen Martínez-Salazar/ Iván Villanueva/ Jorge Pacheco-Rosado/ Claudia Alva-Sánchez

Adult-onset hypothyroidism is associated with an increase in cell atrophy of the hippocampal pyramidal neurons. Physical exercise implies diverse actions on the neural tissue that promote neuron proliferation and survival. The beneficial effects of exercise seem to be inversely linked to its intensity, so that strenuous exercise has reduced protective effects. In this study we evaluated the capacity of a moderate forced-exercise routine to counteract the neurodegenerative effects of a hypothyroi(..)

DOI: 10.21307/ane-2020-005

Hindbrain metabolic deficiency regulates ventromedial hypothalamic nucleus glycogen metabolism and glucose-regulatory signaling

Karen P. Briski/ Santosh K. Mandal

The catecholamine norepinephrine (NE) links hindbrain metabolic-sensory neurons with downstream gluco-regulatory loci, including the ventromedial hypothalamic nucleus (VMN). Exogenous NE up-regulates VMN expression of glutamate decarboxylase (GAD), biomarker for the gluco-inhibitory transmitter γ-aminobutryic acid (GABA). Brain glycogen phosphorylase (GP)-muscle (GPmm) and -brain (GPbb) variants are stimulated in vitro by NE or energy deficiency, respectively. Current research investigated wheth(..)

DOI: 10.21307/ane-2020-006

A ten year longitudinal examination of the incidence rate and age of childhood encephalopathy diagnoses in an autism spectrum disorder diagnosed cohort

Janet K. Kern/ David A. Geier/ Kristin G. Homme/ Mark R. Geier

Autism spectrum disorder (ASD) is defined by persistent deficits in social communication/interaction and stereotypic behaviors with many diagnosed persons experiencing a developmental regression at >1 year-old. It was hypothesized that progressive childhood encephalopathy is an important etiological factor in ASD pathogenesis. This hypothesis-testing study examined the relationship between diagnosed childhood encephalopathy and ASD. The Independent Healthcare Research Database is composed of de-(..)

DOI: 10.21307/ane-2020-007

EEG correlates of cognitive load in a multiple choice reaction task

Sergei A. Schapkin/ Jonas Raggatz/ Markus Hillmert/ Irina Böckelmann

The present study aimed to examine EEG correlates of cognitive load in a task, in which multiple stimulus-response mappings have to be maintained in working memory (WM) combined with selective inhibition of irrelevant stimulus-response mappings on every trial. Twenty-four healthy younger adults had to perform choice reaction tasks differed in the number of S-R mappings and motor response requirements. Performance was lower in the high load than in the low load condition. Performance decline at h(..)

DOI: 10.21307/ane-2020-008

Association between scripture memorization and brain atrophy using magnetic resonance imaging

Mukaila Alade Rahman/ Benjamin Segun Aribisala/ Irfan Ullah/ Hammad Omer

We investigated the association between scripture memorization and brain tissue using magnetic resonance imaging techniques. Participants comprised 63 healthy adults between the ages of 35 and 80 years old with no neurological or psychological disorders. Of these, 19 had completely memorized the Quran, 28 had partially memorized parts of Quran while 16, the control group, had not committed the Quran into their memory. White matter, grey matter and cerebrospinal fluid volumes were calculated. The(..)

DOI: 10.21307/ane-2020-009

No Record Found..

Page Actions

Publications

Acta Neurobiologiae Experimentalis

FEATURED ARTICLES