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Acta Neurobiologiae Experimentalis

Nencki Institute of Experimental Biology

Polish Neuroscience Society

Subject: Behavioral Sciences , Biomedical Sciences & Nutrition , Life Sciences , Medicine , Neurosciences

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ISSN: 0065-1400
eISSN: 1689-0035

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FEATURED ARTICLES

Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
Neuroprotective effects of lipopolysaccharide and naltrexone co-preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat
Differences in spatio-temporal distribution of the visual P3b event-related potential between young men and women
Fos immunoreactivity in the intermediolateral nucleus induced by tendon vibration of the m. triceps surae in rats pretreated with a nitric oxide blocker or precursor

VOLUME 80 , ISSUE 3 (Oct 2020) - List of articles

Modulation of anxiety behavior in gonadectomized animals

Roghaieh Khakpay/ Fatemeh Khakpai

Anxiety is a complex psychological state which happens after stressful life experiences. Many factors such as daily life events, neurotransmitter systems, and different brain areas could influence anxiety behavior in humans and animals. For example, opioids and androgens decrease anxiety behavior both in humans and animals. Furthermore, removing the testes (gonadectomy) causes higher levels of anxiety-like behaviors, in which the administration of testosterone and opioid antagonist can reverse s(..)

DOI: 10.21307/ane-2020-019

Published Online: 15-October-2020

Antistress and antidepressant properties of dapoxetine and vortioxetine

Piotr Ratajczak/ Krzysztof Kus/ Małgorzata Zielińska-Przyjemska/ Beata Skórczewska/ Tomasz Zaprutko/ Dorota Kopciuch/ Anna Paczkowska/ Elżbieta Nowakowska

The studies aimed to determine the antidepressant efficacy of single and chronic administration of dapoxetine alone and vortioxetine alone, as well as in the combination of these drugs. An additional objective of the study was to measure the effect of the active substances on the corticosterone level in chronically stressed animals. The study was conducted on male Wistar rats using non-stressed and stressed groups (chronic restraint stress). The experiment comprised both forced swimming test (im(..)

DOI: 10.21307/ane-2020-020

Published Online: 15-October-2020

RhoA/Rock2/Limk1/cofilin1 pathway is involved in attenuation of neuronal dendritic spine loss by paeonol in the frontal cortex of D-galactose and aluminum-induced Alzheimer’s disease-like rat model

Fei Han/ Hui Xu/ Jun-Xian Shen/ Chuan Pan/ Zong-Hao Yu/ Jing-Jing Chen/ Xiu-Ling Zhu/ Ya-Fei Cai/ Ya-Ping Lu

Alzheimer’s disease (AD) has become the most prevalent neurodegenerative disorder. Given the pathogenesis of AD is unclear, there is currently no drug approved to halt or delay the progression of AD. Therefore, it is pressing to explore new targets and drugs for AD. In China, polyphenolic Chinese herbal medicine has been used for thousands of years in clinical application, and no toxic effects have been reported. In the present study, using D-galactose and aluminum-induced rat model, the effects(..)

DOI: 10.21307/ane-2020-021

Published Online: 15-October-2020

Aerobic exercise has an anxiolytic effect on streptozotocin-induced diabetic rats

Hasan Caliskan/ Firat Akat/ Goktug Omercioglu/ Gulbahar Bastug/ Hakan Ficicilar/ Metin Bastug

Diabetes is a metabolic disorder characterized by hyperglycemia and impaired insulin secretion or action. Psychological comorbidities, such as depression and anxiety, are more common in people with diabetes. Exercise results in anxiolytic effects, as demonstrated in numerous studies. This study aims to evaluate potential anxiolytic effects of aerobic exercise in streptozotocin (STZ)-induced diabetes. Male Wistar albino rats (n=40) were randomly divided into four groups of control, exercise, diab(..)

DOI: 10.21307/ane-2020-022

Published Online: 31-July-2020

Neuromyelitis optica spectrum disorder: an overview

Pooja Ramakrishnan/ Devipriya Nagarajan

Neuromyelitis optica also known as Devic’s syndrome is a rare autoimmune disorder that predominantly targets the optic nerves and the spinal cord. It is a debilitating disorder that damages a person’s health. Initially it was considered as a variant of multiple sclerosis (MS). But, in 2004, a water channel protein associated antibody was found to be responsible for the disease. This helped in distinguishing the disease from multiple sclerosis. Multiple molecular mechanisms like complement depend(..)

DOI: 10.21307/ane-2020-023

Published Online: 15-October-2020

The application of iPSCs in Parkinson’s disease

Josefine Jul Jarbæk Nielsen/ Thea Pinholt Lillethorup/ Andreas Nørgaard Glud/ Jens Christian Hedemann Sørensen/ Dariusz Orlowski

The discovery and application of induced pluripotent stem cells (iPSCs) provide a novel treatment modality for diseases, which remain incurable. Particularly, in the treatment of neurodegenerative diseases such as Parkinson’s disease (PD), iPSC-technology holds an interesting prospect for replacement therapy. Currently, the prognostic improvement of PD is limited and relies on symptomatic treatment. However, the symptomatic dopamine-replacement therapies lose their long-duration responses, and n(..)

DOI: 10.21307/ane-2020-024

Published Online: 15-October-2020

Subchronic effects of ligands of cannabinoid receptors on learning and memory processes of olfactory bulbectomized rats

Margarita Velikova/ Dobrinka Doncheva/ Roman Tashev

The brain endocannabinoid system has been shown to play a role in many physiological processes, including mood, learning and memory. It is also involved in the pathogenesis of anxiety, depression, mood disorders, as well as neurodegenerative disorders, although the exact mechanisms by which cannabinoid receptors interfere in these disorders are not well established. The aim of the present study was to evaluate the effects of cannabinoid ligands HU-210 (CB1 receptor agonist) and SR 141716A (CB1 r(..)

DOI: 10.21307/ane-2020-025

Published Online: 15-October-2020

Serum levels of hepcidin and interleukin 6 in Parkinson’s disease

Jolanta Kwiatek-Majkusiak/ Maciej Geremek/ Dariusz Koziorowski/ Ryszard Tomasiuk/ Stanisław Szlufik/ Andrzej Friedman

Neurodegeneration in Parkinson’s disease (PD) includes processes of chronic inflammation and oxidative stress which are related to dysregulation in the homeostasis of iron metabolism. Hepcidin is a peptide hormone responsible for systemic iron homeostasis and simultaneously the inflammatory response protein, induced in response to interleukin 6 (IL-6). We assessed the serum concentration of hepcidin and IL-6 in the groups of patients with PD treated only pharmacologically with optimal individual(..)

DOI: 10.21307/ane-2020-026

Published Online: 15-October-2020

Phenylbutyrate administration reduces changes in the cerebellar Purkinje cells population in PDC-deficient mice

Ilona Klejbor/ Saleh Mahmood/ Natalia Melka/ Adriana Ebertowska/ Janusz Morys/ Ewa K. Stachowiak/ Michal K. Stachowiak/ Mulchand S. Patel

In humans, pyruvate dehydrogenase complex (PDC) deficiency impairs brain energy metabolism by reducing the availability of the functional acetyl-CoA pool. This “hypometabolic defect” results in congenital lactic acidosis and abnormalities of brain morphology and function, ranging from mild ataxia to profound psychomotor retardation. Our previous study showed reduction in total cell number and dendritic arbors in the cerebellar Purkinje cells in systemic PDC-deficient mice. Phenylbutyrate has bee(..)

DOI: 10.21307/ane-2020-027

Published Online: 15-October-2020

Diazepam and electrical stimulation of paleocerebellar cortex inhibits seizures in pentylenetetrazol-kindled rats

Leonid S. Godlevsky/ Oleksii O. Shandra/ Mykhailo P. Pervak/ Alexey A. Shandra

The cerebellum is a potent anti-epileptic target for deep brain stimulation in patients with drug-resistant epilepsy. The effects of such stimulation, however, may also favor seizure activity. Our goal was to investigate the effect of cerebellar electrical stimulation (ES) alone and in combination with the anti-epileptic drug diazepam (DIA) on seizure outcome. We used a rat model of pentylenetetrazol kindling, which is characterized by seizures followed by deteriorations in central benzodiazepin(..)

DOI: 10.21307/ane-2020-028

Published Online: 15-October-2020

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