VOLUME 23 , ISSUE 1 (June 2015) - List of articles

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The pathophysiology of Lennox-Gastaut syndrome – a review of clinico-electrophysiological studies

Kazuichi Yagi

Introduction. Lennox-Gastaut syndrome (LGS) is a type of therapy-resistant epileptic syndrome. Since the establishment of our Epilepsy Center in 1975 we have performed many studies to assess the clinical symptoms, seizure manifestations, sleep and long-term follow-up of the clinical course and changes on electroencephalographs (EEGs) in patients with LGS. Aim. To review the updated pathophysiology of LGS based on our own clinico-electrophysiological data referring to recent advances in brain res(..)

DOI: 10.1515/joepi-2015-0021

Published Online: 02-January-2015

Variations in cognitive functioning in genetic generalized epilepsy: four case studies

Evangelina E. Ballini/ Edward Helmes/ Bruce K. Schefft

Introduction. The traditional view of cognition in idiopathic or genetic generalized epilepsy (GGE) is that “one size fits all” i.e. only very mild generalized impairment might be detected, if any. This paper describes four case studies of cognitive functioning in GGE patients with photosensitivity and reflexive seizures. Aim. The aim was to discover whether each individual’s set of cognitive deficits varied in accordance with his/her other clinical phenomena such as photosensitivity and kinds o(..)

DOI: 10.1515/joepi-2015-0024

Published Online: 31-March-2015

The ILAE definition of drug resistant epilepsy and its clinical applicability compared with “older” established definitions

Alexandra Rohracher/ Judith Dobesberger/ Claudia A. Granbichler/ Julia Höfler/ Giorgi Kuchukhidze/ Martin Ortler/ Iris Unterberger/ Gerald Walser/ Aljoscha Thomschewski/ Eugen Trinka

Background. Early identification of potential epilepsy surgery candidates is essential to the treatment process. Aim. To evaluate the clinical applicability of the ILAE definition of drug resistant epilepsy and its potential in identifying surgical candidates earlier compared to three established “older” definitions of drug resistant epilepsy. Material and methods. Retrospective analysis of 174 patients who underwent epilepsy surgery between 1998 and 2009. Clinical factors and course of disease (..)

DOI: 10.1515/joepi-2015-0025

Published Online: 02-April-2015

Neurostimulation, neuromodulation, and the treatment of epilepsies

Lauren B. Bolden/ Sandipan Pati/ Jerzy P. Szaflarski

Introduction. Neurostimulation and neuromodulation are techniques that may be able to affect the course of epilepsy. In the last 20 years, since the approval of VNS, we have observed a surge of studies assessing the potential of other devices and techniques for the treatment of pharmacoresistant epilepsies including deep brain stimulation (DBS), responsive neurostimulation (RNS), trigeminal nerve stimulation (TNS), transcranial direct current stimulation (tDCS), and repetitive transcranial magne(..)

DOI: 10.1515/joepi-2015-0022

Published Online: 19-January-2015

Epileptic seizure propagation from the second somatic sensory area to the fronto-medial region, by insular redistribution. A case report and a connectome description

Attila Balogh/ Péter Halász/ Dániel Fabó/ Lóránd Erőss

Introduction. The seizure propagation phenomenon by inducing remote symptoms brings several difficulties in finding the seizure onset and delineating the epileptic network which should be taken into consideration in epilepsy surgery. By demonstrating a difficult (MRI negative) epilepsy surgery case explored with invasive presurgical evaluation we highlight the importance to recognise the secondary sensory area and to explore the the parieto-opercular-insular-medial frontal network in certain cas(..)

DOI: 10.1515/joepi-2015-0023

Published Online: 27-February-2015

Cognitive functions in myoclonic epilepsy with ragged red fibres – a case report

Martyna Domańska/ Emilia J. Sitek/ Michał Schinwelski/ Maria Mazurkiewicz-Bełdzińska/ Agnieszka Matheisel/ Jarosław Sławek

Introduction. Myoclonic epilepsy with ragged red fibers (MERRF) is a rare, progressive mitochondrial disease affecting multiple systems, including the central nervous system. Typical MERRF symptoms include: myoclonus, epileptic seizures, ataxia and cognitive decline. In mitochondrial diseases selective cognitive impairment or generalized decline, called mitochondrial dementia, is usually diagnosed. Description of case. We present the case of an 18-year-old patient with progressive neurological s(..)

DOI: 10.1515/joepi-2015-0026

Published Online: 05-May-2015

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