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Journal of Epileptology

Foundation of Epileptology

Subject: Medicine


eISSN: 2300-0147



The potential mechanisms of effect of valproic acid on lipid profiles: an updated review
Ketogenic diet in epilepsy: an updated review
The interrelationship between clinical and immunity variables in epilepsy

VOLUME 24 , ISSUE 1 (June 2016) - List of articles

Russian experience of using perampanel in daily clinical practice. Preliminary report

Pavel Vlasov/ Vladimir Karlov/ Irina Zhidkova/ Aleksandr Chervyakov/ Oleg Belyaev/ Iosif Volkov/ Diana Dmitrenko/ Antonina Karas/ Tatiana Kazennykh/ Olga Miguskina/ Anna Moskvicheva/ Elena Paramonova/ Irina Ponomareva

Introduction. Perampanel (PER) (Fycompa) 5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1'H)-on is the newest antiepileptic drug and is the first-in-class selective non-competitive antagonist of ionotropic AMPA glutamate receptors of the postsynaptic neuronal membrane. The aim was to summarize Russian experience in using PER in daily clinical practice, and for this purpose the results of its use as an add-on treatment for focal epilepsy were assessed retrospectively Material and Method. The re(..)

DOI: 10.1515/joepi-2016-0007

Published Online: 24-June-2016

Lateralized periodic discharges associated with status epilepticus in the first year after stroke

Hava Ozlem Dede/ Nerses Bebek/ Ozlem Gelisin/ Murat Mert Atmaca/ Nilufer Yesilot Barlas/ Candan Gurses/ Betul Baykan/ Aysen Gokyigit

Backgrand. Lateralized periodic discharges (LPDs) are infrequent electroencephalograph (EEG) findings, and may present in ictal or interictal form. They are regarded as potential electrophysiologic signs of convulsive or nonconvulsive status epilepticus (NCSE). We report four patients who presented with NCSE and one who presented with convulsive status epilepticus in the postictal period, characterized by LPDs in EEG recordings in the first year after stroke. Material and methods. We prospective(..)

DOI: 10.1515/joepi-2016-0002

Published Online: 17-March-2016

Natural course of treated epilepsy and medico-social outcomes. Turku studies. Part II

Matti Sillanpää

Introduction. Population-based data on the prognosis of childhood-onset epilepsy were almost nonexistent in the 1960s. This prompted me to start an epidemiological prospective study on children with epilepsy. Aim. To study the medical and social outcome of children with epilepsy. Methods. The most important personal data on the natural course and outcome were reviewed and compared with the relevant data of other investigators. Results and discussion. The natural course of treated epilepsy is rem(..)

DOI: 10.1515/joepi-2016-0001

Published Online: 25-January-2016

Anticonvulsant therapy in brain-tumor related epilepsy

Walter Fröscher/ Timo Kirschstein/ Johannes Rösche

Background. The lifetime risk of patients with brain tumors to have focal epileptic seizures is 10–100%; the risk depends on different histology. Specific guidelines for drug treatment of brain tumor-related seizures have not yet been established. Aim. This review addresses the special aspects of antiepileptic drug (AED) therapy in brain tumor-related epilepsy. Methods. We analyzed the literature up to December 2015. Results. Based on current evidence the management of tumor-related seizures doe(..)

DOI: 10.1515/joepi-2016-0004

Published Online: 06-April-2016

Depression and anxiety in people with epilepsy: Why should we identify?

Sung-Pa Park

Introduction. People with epilepsy (PWE) have a higher risk of developing depression and anxiety than people without epilepsy. However, understanding and management of that issue remain under-recognized. Aim. To emphesize: a) the relationship between depression, anxiety, and epilepsy, and b) to suggest practical strategies for their identification by clinicians. Methods. The current literatures was reviewed investigating the impact of depression and anxiety in PWE and those examining the validit(..)

DOI: 10.1515/joepi-2016-0005

Published Online: 07-June-2016

Concomitant treatment with imipenem causes a rapid and extensive decrease in the plasma concentrations of valproic acid

Tapani Keränen/ Hanna Kuusisto

Background. Valproic acid (VPA) is a wide-spectrum antiepileptic drug used both in children and in adults. We describe a clinically important interaction between VPA and imipenem, a carbapenem antimicrobial. Case presentation. Our patient was a 19-year-old man with childhood onset of mental retardation and severe epilepsy. He was hospitalized due to pneumonia. His antiepileptic drugs, including VPA, were administered intravenously. Due to pneumonia, intravenously administered imipenem was starte(..)

DOI: 10.1515/joepi-2016-0006

Published Online: 15-June-2016

Successful treatment of epilepsia partialis continua due to Rassmussen encephalitis with perampanel

Katja Göde/ Annette Grossmann/ Johannes Rösche

Background. Epilepsia partialis continua (EPC) is a difficult to treat condition, which tends to be refractory to antiepileptic drugs (AEDs). We previously published two other treatment episodes of EPC due to stroke and vascular dementia with a possible effect of perampanel (PER). Aim. With the publication of a third treatment episode of EPC terminated by the administration of PER we would like to suggest that PER may be an effective treatment option in this condition. Material and Methods. We p(..)

DOI: 10.1515/joepi-2016-0003

Published Online: 31-March-2016

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