The role of the hepatic metabolisation for the interaction between valproic acid and carbapenem antibiotics

Johannes Rösche

DOI: 10.1515/joepi-2016-0008

Published Online: 07-September-2016

Additive interactions between retigabine and oxcarbazepine in the chimney test and the model of generalized tonic-clonic seizures in mice

Mirosław Zagaja/ Barbara Miziak/ Katarzyna Załuska/ Paweł Marzęda/ Bartłomiej Drop/ Karolina Załuska-Patel/ Grażyna Ossowska/ Stanisław J. Czuczwar/ Jarogniew J. Łuszczki

Introduction. Patients with pharmacoresistant epilepsy are usually treated with two or more antiepileptic drugs (AEDs). The search for therapeutically efficacious AED combinations is still a challenging issue for clinicians and epileptologists throughout the world. Aim. To determine the interaction profile for the combination of retigabine (RTG) and oxcarbazepine (OXC) in both, the model of tonic-clonic seizures, the maximal electroshock (MES)-induced seizure model and chimney test (motor perfor(..)

DOI: 10.1515/joepi-2016-0016

Published Online: 22-December-2016

The interrelationship between clinical and immunity variables in epilepsy

Vladimir V. Kalinin/ Kirill Y. Subbotin/ Natalia G. Yermakova

Introduction. The role of cellular immunity in the pathogenesis of epilepsy, as an interaction between immunity and clinical and neurobiological variables is not properly understood. Aim. The aim of the current study was to investigate the possible relationship between epilepsy forms, gender, focus localization, lateralization, handedness and cellular immunity with seizures frequency, their severity and length of therapeutic remission in partial forms of epilepsy. Material and methods. Ninety tw(..)

DOI: 10.1515/joepi-2016-0015

Published Online: 22-December-2016

The quality of life of children with epilepsy in Poland – the opinion of children and their parents

Dorota Talarska/ Michał Michalak/ Patrycja Talarska

Background. Every chronic illness, including epilepsy, has a negative effect on both the quality of life of the sufferer as well as on their relationship with their surroundings. Aims. To investigate the quality of life of children suffering from epilepsy and analyse how they assessed and scored their experiences compared to their parents. Materials and methods. The study included 209 children with epilepsy and their parents. The research tool was a questionnaire for gathering demographic and cl(..)

DOI: 10.1515/joepi-2016-0012

Published Online: 19-December-2016

Presurgical diagnosis of epilepsies – concepts and diagnostic tools

Heinz Gregor Wieser

Introduction. Numerous reviews of the currently established concepts, strategies and diagnostic tools used in epilepsy surgery have been published. The focus concept which was initially developed by Forster, Penfield and Jasper and popularised and enriched by Luders, is still fundamental for epilepsy surgery. Aim. To present different conceptual views of the focus concept and to discuss more recent network hypothesis, emphasizing so-called "critical modes of an epileptogenic circuit". Method. A (..)

DOI: 10.1515/joepi-2016-0014

Published Online: 22-December-2016

The medial temporal lobe epilepsy is a bilateral disease – novel aspects

Péter Halász

Introduction. Medial temporal lobe epilepsy (MTLE) is the most frequent form of epilepsy in adulthood. It is classified as local/regional epilepsy. However, there is increasing evidence of the involvement of both temporal lobes and this provides abundant arguments to question this view, and consider MTLE as one of the typical bilateral system epilepsies. Aim. To provide a contemporary review of medial temporal lobe epilepsy, discussing the bilateral aspects, with reference to epilepsy surgery. M(..)

DOI: 10.1515/joepi-2016-0010

Published Online: 22-November-2016

The relationship of medial temporal lobe epilepsy with the declarative memory system

Péter Halász

Introduction. Medial temporal lobe of epilepsy (MTLE) is considered as local/regional epilepsy. However, as was discussed in Part I of this review (Halasz, 2016a) there is more evidence regarding the involvement of both temporal lobes so as to consider MTLE as one of the typical bilateral system epilepsies. Aim. To provide contemporary review of MTLE in relation to the declarative memory system and the newly recognized hippocampo-frontal memory consolidation during slow wave sleep. Methods. A re(..)

DOI: 10.1515/joepi-2016-0011

Published Online: 22-November-2016

The epileptic multifactorial patient’s burden. Review of the topic

José Pimentel

Background. Approximately 26% of the burden of neurologic diseases is due to epilepsy. Its negative impact reflects mainly on people with epilepsy (PWE) themselves. Aims. To highlight the negative impacts of epilepsy on the lives of PEWs so as to identify a realistic approach to their individual needs. Methods. For recently published papers PubMed and MEDLINE databases were used. In addition relevant references mentioned in the searched articles were also considered. Review and discussion. Gener(..)

DOI: 10.1515/joepi-2016-0009

Published Online: 30-September-2016

Biofeedback as complementary treatment in patients with epilepsy – an underestimated therapeutic option? Review, results, discussion

Carmen Uhlmann/ Walter Fröscher

Background. Biofeedback methods represent side effect free complementary options in the treatment of epilepsy. In this paper we review the current status of these methods in terms of clinical study results and their evaluation by systematic review papers. Possible mechanisms of action in biofeedback methods are discussed. Aim. To present the current status of biofeedback methods applied to patients with epilepsy. Material and Methods. With a literature search up to 10/2016 we screened publicatio(..)

DOI: 10.1515/joepi-2016-0013

Published Online: 17-December-2016