Do minocycline and other suppressors of microglia reactivity have a future in prevention or treatment of epilepsy?
Władysław Lasoń/ Joanna Ślusarczyk/ Magdalena Regulska/ Monika Leśkiewicz/ Agnieszka Basta-Kaim
Introduction. An increasing body of evidence points to an important role of neuroinflammatory processes in the pathomechanism of epilepsy. This hypothesis is mainly supported by data showing an increase of pro-inflammatory cytokine levels and glia activation in animal models of epilepsy and in brain tissue of epileptic patients. On the other hand, less emphasis has been put on pharmacological verification of this hypothesis. Aim. The aim of this review is to summarize current knowledge on potent(..)
Published Online: 30-August-2017