VOLUME 25 , ISSUE 1-2 (December 2017) - List of articles

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Do minocycline and other suppressors of microglia reactivity have a future in prevention or treatment of epilepsy?

Władysław Lasoń/ Joanna Ślusarczyk/ Magdalena Regulska/ Monika Leśkiewicz/ Agnieszka Basta-Kaim

Introduction. An increasing body of evidence points to an important role of neuroinflammatory processes in the pathomechanism of epilepsy. This hypothesis is mainly supported by data showing an increase of pro-inflammatory cytokine levels and glia activation in animal models of epilepsy and in brain tissue of epileptic patients. On the other hand, less emphasis has been put on pharmacological verification of this hypothesis. Aim. The aim of this review is to summarize current knowledge on potent(..)

DOI: 10.1515/joepi-2017-0003

Published Online: 30-August-2017

Adenosine receptor agonists differentially affect the anticonvulsant action of carbamazepine and valproate against maximal electroshock test-induced seizures in mice

Mirosław Jasiński/ Magdalena Chrościńska-Krawczyk/ Stanisław J. Czuczwar

Background. Adenosine is regarded as an endogenous anticonvulsant and its agonists have been proved to affect the anticonvulsant activity of a number of antiepileptic drugs (AEDs) in animal models of seizures. Aim. To evaluate effects of adenosine agonists on carbamazepine (CBZ) and valproate (VPA) in mouse model of generalized tonic-clonic convulsions. Methods. The following adenosine receptor agonists were used: A 1 – cyclohexyladenosine, A2A – CGS 21 680, A3 – N6-benzyl-NECA and A 1 (preferen(..)

DOI: 10.1515/joepi-2017-0006

Published Online: 15-January-2018

Diagnoses and referral pattern at a first seizure clinic in London

Duncan Palka/ Mahinda Yogarajah/ Hannah R. Cock/ Marco Mula

Background. Epilepsy is among the most frequent neurological conditions and it is estimated that approximately 8% of the population experience a seizure at some time in their lives. Aim. To examine the characteristics of patients referred to a First Seizure Clinic (FSC) at a University Hospital in South-West London. Methods. All subjects referred to the FSC at St George’s University Hospitals between January and December 2015 were included in this audit. Results. From a total of 257 patients, ma(..)

DOI: 10.1515/joepi-2017-0004

Published Online: 14-November-2017

Actions related to International Bureau for Epilepsy during my term as President 2013–2017

Athanasios Covanis

The International Bureau for Epilepsy (IBE) Executive Committee for the term 2013–2017 began in June 2013 during the 30th International Epilepsy Congress in Montreal. From the beginning, our primary goals were to fulfil the mission of our organisation and address problems such as awareness, education, and social issues, while promoting and protecting the human rights of persons with epilepsy (PWE) and improving trans-regional equity in access to health care services, improved prevention, diagnos(..)

DOI: 10.1515/joepi-2017-0005

Published Online: 13-December-2017

Clinical report: a rare co-occurrence of tuberous sclerosis complex and Rett syndrome in a girl with mental retardation, epilepsy and autism

Elena Belousova/ Vladimir Sukhorukov/ Marina Dorofeeva/ Lev Shagam/ Dmitrii V. Vlodavetz

Introduction. There are some genetic disorders with combination of mental retardation, epilepsy and autism in which the abnormal mammalian Target of Rapamycin (m-TOR) signaling is implicated. The most important of them is tuberous sclerosis complex (TSC), but the disturbances of the m-TOR pathway can also be detected in Rett syndrome (RS), Fragile X syndrome and Down syndrome. We describe the rare case of co-occurrence of TSC and RS. Case study. The female child was born at term by normal delive(..)

DOI: 10.1515/joepi-2017-0002

Published Online: 08-August-2017

The diagnostic dilemma of non-convulsive status epilepticus in sporadic Creutzfeldt-Jakob disease

Matthias Wittstock/ Uwe Walter/ Daniela Schirrmeister/ Kyrylo Kurtieiev/ Jan Klinke/ Annette Grossmann/ Johannes Rösche

Introduction. The differentiation between the clinical and electroencephalographic changes in nonconvulsive status epilepticus (NCSE) and those in sporadic Creutzfeldt-Jakob disease (sCJD) is a crucial question. Case report. A 77-year old woman was admitted because of fluctuating behavioural chancaseges, adynamia and apraxia since several months for diagnostic. The diagnosis of sCJD was suggested. Subsequently, she had a generalized tonic clonic seizure (GTCS) and the EEG revealed periodic later(..)

DOI: 10.1515/joepi-2017-0001

Published Online: 05-June-2017

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