VOLUME 59 , ISSUE 1 (Mar 2020) - List of articles

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FROM GREAT GENETICS TO NEUROPSYCHOLOGY – OUTLINE OF THE RESEARCH ON THE ASSOCIATION BETWEEN MICROBIOTA AND HUMAN BEHAVIOUR

Dominik Czajeczny/ Karolina Kabzińska/ Rafał Wojciech Wójciak

Abstract After the success of the Human Genome Project, which lead to estimating the number of human genes at only about 30–40 thousand, researchers started paying attention to a great number of genes present inside and on the surface of the human body. The gastrointestinal tract alone is a habitat for up to 1000 species of bacteria and other microorganisms. These microorganisms add a pool of 2–4 million additional genes. In 2009, a hypothesis was proposed that changes in microbiota are sensed b(..)

DOI: 10.21307/PM-2020.59.1.001

CAUSES OF PERTUSSIS INCIDENCE INCREASE

Marta Prygiel/ Ewa Mosiej/ Aleksandra Anna Zasada

Abstract Bordetella pertussis is an etiological factor of whooping cough. Despite global vaccination programs, this disease remains endemic in many countries and is still recognized as a significant public health problem. It is estimated that in 2014, around 24 million people worldwide contracted pertussis, of whom 160,700 children under the age of 5 died. Two types of pertussis vaccines are available: suspensions based on whole, killed, B. pertussis cells and acellular pertussis vaccines contai(..)

DOI: 10.21307/PM-2020.59.1.002

THE ROLE AND IMPORTANCE OF SELECTED VIRULENCE FACTORS DETERMINING THE PATHOGENICITY OF UROPATHOGENIC ESCHERICHIA COLI STRAINS

Sylwia Joanna Chmielewska/ Katarzyna Leszczyńska

Abstract The most frequent etiologic agents of the urinary tract infections (UTIs) are UPEC strains (Uropathogenic Escherichia coli), which are responsible for 75–95% of UTIs. The virulence factors of UPEC bacteria, as well as their ability to form biofilm, play a significant role in the pathogenicity of UTIs. Limiting iron availability is a major host defense against the growth of microorganisms within hosts. That is why UPEC strains produce various types of siderophores as well as siderophore (..)

DOI: 10.21307/PM-2020.59.1.003

SACCHAROMYCES CEREVISIAE VAR. BOULARDII IN IRRITABLE BOWEL SYNDROME

Przemysław Gałązka/ Aleksandra Baska/ Jakub Kazik/ Kamil Leis

Abstract Probiotics are organisms which belong to the fungi or bacteria groups and affect e.g., bacterial flora in the intestinum or inflammation site by reduction of the condition. They are applied in many cases, such as food allergies, diarrhea, autoimmunologic disorders, and irritable bowel syndrome (IBS) that affects 10% of the world population. Due to the lack of proper pharmacological treatment which would result in complete remission, probiotic preparations which lead to a reduction of th(..)

DOI: 10.21307/PM-2020.59.1.004

ANTIBIOTICS AND BACTERIA: MECHANISMS OF ACTION AND RESISTANCE STRATEGIES

Magdalena Skarżyńska/ Magdalena Zając/ Dariusz Wasyl

Abstract The resistance of bacteria to antimicrobial substances is one of the most serious epidemiological problems present on a global scale. The widespread use of same classes of antimicrobials in human and veterinary medicine, often without laboratory confirmation of the efficacy of active compounds used, contributes to the selection of resistant bacteria in humans and animals, and their spread in nature. The increasing resistance of pathogenic bacteria leads to serious consequences for both (..)

DOI: 10.21307/PM-2020.59.1.005

CLINICALLY USED AND POTENTIAL ANTIMYCOTICS IN THE CONTEXT OF THERAPY OF DERMATOMYCOSES

Sebastian Gnat/ Dominik Łagowski/ Aneta Nowakiewicz/ Mariusz Dyląg

Abstract Paradoxically, despite the progress in medicine, the prevalence of fungal infections is increasing from year to year. At the beginning of the third millennium, practical therapeutic options are still very limited. Currently, only eight classes of antifungal compounds are in clinical use, only four of which are used in the treatment of dermatomycoses. The intense search for the “Holy Grail” of antifungal therapy that has been going on since the second half of the 20th century faces serio(..)

DOI: 10.21307/PM-2020.59.1.006

BIOTECHNOLOGICAL AND BIOMEDICAL APPLICATIONS OF FUNGAL CELLOBIOSE DEHYDROGENASE

Katarzyna Olszewska/ Anna Olszewska/ Jerzy Rogalski/ Justyna Sulej

Abstract Cellobiose dehydrogenase (CDH) is an extracellular oxidoreductive enzyme produced by wood-decaying fungi belonging to the phylum Basidiomycota and Ascomycota. This enzyme has a binary structure containing two cofactors (FAD and hem), located in separate domains and connected by a proteolytically sensitive linker. Due to its unique structure and properties, CDH has great potential for application in both biotechnology and biomedical applications. The aim of this paper is to review the li(..)

DOI: 10.21307/PM-2020.59.1.007

BIONANOCELLULOSE – PROPERTIES, ACQUISITION AND PERSPECTIVES OF APPLICATION IN THE FOOD INDUSTRY

Remigiusz Olędzki/ Ewa Walaszczyk

Abstract The food industry is one area of industrial activities that requires the frequent implementation of technological and product innovations. Foodstuffs obtained both in technologically advanced factories, as well as in small manufacturing enterprises, are increasingly produced using innovative food additives, which include natural polysaccharide ingredients. One of these substances is bionanocellulose – microbially produced cellulose (most commonly by the genus Komagataeibacter xylinus, f(..)

DOI: 10.21307/PM-2020.59.1.008

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