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Journal of Blood Group Serology and Molecular Genetics

American National Red Cross

Subject: Medical Laboratory Technology


ISSN: 0894-203X
eISSN: 1930-3955



VOLUME 33 , ISSUE 3 (September 2017) - List of articles

ABO serology in a case of persistent weak A in a recipient following a group O–matched unrelated bone marrow transplant

Dianne E. Grey/ Elizabeth A. Fong/ Catherine Cole/ Jesper Jensen/ Jill Finlayson

HLA-matched hematopoietic stem cell transplantation (HSCT) from red blood cell (RBC)-incompatible donors is not uncommon. The engraftment process following ABO-incompatible allogeneic HSCT results in the transition from patient blood group to donor blood group in the recipient. In contrast, most non-hematopoietic tissues retain expression of the patient’s original blood group for life, and these antigens may adsorb from the plasma onto the donor-derived RBCs. Correct serologic interpretation of (..)

DOI: 10.21307/immunohematology-2019-014

Stability guidelines for dithiothreitol-treated red blood cell reagents used for antibody detection methods in patients treated with daratumumab

Wendy L. Disbro

Daratumumab (DARA), a drug used to treat patients with multiple myeloma, causes interference in pre-transfusion testing. Samples from patients receiving DARA exhibit panreactivity in antibody detection and identification tests with red blood cells (RBCs). Many hospitals are sending these samples to reference laboratories. Dithiothreitol (DTT), a sulfhydryl chemical treatment of RBCs, negates this reactivity. This study investigated the stability of the antigens on DTT-treated RBCs to determine i(..)

DOI: 10.21307/immunohematology-2019-015

A LU:−16 individual with antibodies

Carole Éthier/ Cynthia Parent/ Anne-Sophie Lemay/ Nadia Baillargeon/ Geneviève Laflamme/ Josée Lavoie/ Josée Perreault/ Maryse St-Louis

Antibodies against Lutheran blood group antigens have been observed during first-time pregnancy. Samples from a woman of African descent were tested in our immunohematology laboratory on several occasions since 2001. Her samples were phenotyped as Lu(a+b−), and anti-Lub was suspected but not identified. She was asked to make autologous donations in preparation for her delivery, which she did. In 2010, two antibodies were identified: anti-Lea and -Lub. Six years later, a third investigation was r(..)

DOI: 10.21307/immunohematology-2019-016

Postpartum acute hemolytic transfusion reactions associated with anti-Lea in two pregnancies complicated by preeclampsia

Marcia Marchese

Lewis blood group antibodies, which are mostly naturally occurring and considered clinically insignificant, have rarely been documented as a cause of acute hemolytic transfusion reactions (AHTRs). This report presents two cases of AHTRs caused by anti-Lea occurring in postpartum black females (one group B, one group AB) whose pregnancies were complicated by preeclampsia. Neither anti-Lea was detected by automated solid-phase red cell adherence technology in pre-transfusion testing. Therefore, re(..)

DOI: 10.21307/immunohematology-2019-017

Red blood cell phenotype prevalence in blood donors who self-identify as Hispanic

Chelsea A. Sheppard/ Nicole L. Bolen/ Beth Eades/ Gorka Ochoa-Garay/ Mark H. Yazer

Molecular genotyping platforms provide a quick, high-throughput method for identifying red blood cell units for patients on extended phenotype-matching protocols, such as those with sickle cell disease or thalassemia. Most of the antigen prevalence data reported are for non-Hispanic populations. Therefore, this study sought to determine the phenotype prevalence in a single blood center’s Hispanic population and to compare those results with previously reported rates in non-Hispanic donor populat(..)

DOI: 10.21307/immunohematology-2019-018

DEL phenotype

Dong Hyang Kwon/ S. Gerald Sandler/ Willy Albert Flegel

DEL red blood cells (RBCs) type as D– by routine serologic methods and are transfused routinely, without being identified as expressing a very weak D antigen, to D– recipients. DEL RBCs are detected only by adsorption and elution of anti-D or by molecular methods. Most DEL phenotypes have been reported in population studies conducted in East Asia, although DEL phenotypes have been detected also among Caucasian individuals. Approximately 98 percent of DEL phenotypes in East Asians are associated (..)

DOI: 10.21307/immunohematology-2019-019

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