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North American Journal of Medicine and Science

American Chinese Medical Exchange Society

Acmes Publications Inc

Subject: Medicine

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ISSN: 1946-9357
eISSN: 2156-2342

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FEATURED ARTICLES

Concomitant 1q42.13-q44 Duplication and 14q32.33 Deletion: A Case Report and Review of Literature
Screening Genetic Alterations of Biomarkers BRAF, ROS-1, and HER2 by Immunohistochemistry in Ovarian Carcinomas for Targeted Therapy

VOLUME 11 , ISSUE 1 (March 2018) - List of articles

Clinicopathologic Characteristics of EGFR Mutations in Non-Small Cell Lung Cancer (NSCLC) in Central New York

Daniel J. Zaccarini/ Brittany Depasquale/ Aarati Poudel/ Steven Graziano/ Shengle Zhang

EGFR mutation rates in NSCLC differ among ethnic groups, nations, age, sex, smoking status, and histologic differentiation. We examined the clinicopathologic characteristics of EGFR mutations in NSCLC in the Central New York (CNY) region for the first time, to further characterize the disease and facilitate management. 7.1% (33/464) NSCLCs were positive for EGFR mutations. Based on available clinical data, EGFR positive mutation status was found in 7.4% (28/380) White, 5.3% (2/38) African Americ(..)

DOI: 10.7156/najms.2018.1101001

Published Online: 01-March-2018

Autoimmune Hepatitis: Clinical Overview and Pathological Findings

Simpal Gill

Autoimmune hepatitis (AIH) is an uncommon cause of severe chronic hepatitis with a female predilection and affecting all ages and ethnic groups. Although its pathogenesis is still not completely clear, the condition has been linked to dysimmunoregulation of T lymphocytes, which attack and damage the hepatic parenchyma. Characteristic autoantibodies are produced against hepatocytes leading to cell injury and necrosis, eventually progressing to cirrhosis in a subset of patients. The goal of treatm(..)

DOI: 10.7156/najms.2018.1101006

Published Online: 01-March-2018

Ectopic Hamartomatous Thymoma: A Case Report and Literature Review

Zhiwei Yin/ Ruifang Zheng/ Charvi Cassano/ Ozlem Fidan-Ozbilgin/ Shahida Ahmed/ Donghong Cai

Ectopic hamartomatous thymoma is a rare benign tumor located at supraclavicular/suprasternal area and is speculated with a branchial anlage origin. There are usually 3 components in the tumor: spindle cells, epithelial cells, and adipose tissue, although proportion of each varies from case to case. The tumor cells present with a unique immunophenotype, with strong positivity for AE1/AE3, CD34, CD10, and variable staining for Bcl-2 and SMA. Here we report such a case in a 61-year-old male, with a(..)

DOI: 10.7156/najms.2018.1101011

Published Online: 01-March-2018

Cutaneous Epithelioid Malignant Peripheral Nerve Sheath Tumor: A Case Report

Christopher A. D’Angelis/ David M. Crossland

Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma arising from neuroectoderm-derived cells comprising the outer coverings of peripheral nerves. Given the diverse cell types comprising the peripheral nerve sheath, both benign and malignant nerve sheath tumors display a wide range of histologic appearances. MPNST can arise either in association with proximal nerve trunks at deep body sites, or from distal nerve branches residing within skin and subcutaneous tissues. Ove(..)

DOI: 10.7156/najms.2018.1101015

Published Online: 01-March-2018

Colonic Mucosal Schwann Cell Hamartoma: A Case Report and Literature Review

Ruifang Zheng/ Donghong Cai

Colonic mucosal Schwann cell hamartoma is an extremely rare entity, presenting as small colonic polyp, associating with no clinical symptoms and harboring no clinical significance. However, its mimics, such as GI neurofibroma/neurofibromatosis, ganglioneuroma, etc. are possible GI manifestations of hereditary syndromes and therefore are integral part of the patient workup and disease diagnosis. Here we report a case of mucosal Schwann cell hamartoma, with description of its morphology and immuno(..)

DOI: 10.7156/najms.2018.1101019

Published Online: 01-March-2018

Alopecia Areata and Scarring Alopecia Presenting During Golimumab Therapy for Ankylosing Spondylitis

Melissa M. Helm/ Stefanos Haddad

Golimumab is a human monoclonal antibody useful in the treatment of a wide variety of inflammatory conditions including ankylosing spondylitis, rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Golimumab’s clinical efficacy is attributed to its inhibition of tumor necrosis factor alpha (TNF-α). As more individuals have been treated with anti-TNF-α therapy, increased numbers of side effects have been identified. We report a patient with a long history of ankylosing spondylitis an(..)

DOI: 10.7156/najms.2018.1101022

Published Online: 01-March-2018

Primary Prostatic High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements: A Case Report and Literature Review

Zhiwei Yin/ Ruifang Zheng/ Donghong Cai

Prostatic lymphoma (mostly secondary involvement) is rare, accounting for 0.09% of all prostate tumors and 0.1% of non-Hodgkin lymphoma. Primary prostate lymphoma is extremely rare, by far only limited number of cases have been reported in English literature. Here we report a case of primary prostatic high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBCL-MBBR) in an 81-year-old Caucasian male who presented with urinary outlet obstruction as sole symptom. He was diagnosed(..)

DOI: 10.7156/najms.2018.1101025

Published Online: 01-March-2018

New Onset Epilepsia Partialis Continua Presenting as Complex Visual Hallucinations associated with Voltage-Gated Potassium Channel Antibody

Svetlana P. Eckert/ Ping Li

A 54-year old female with past medical history significant for rheumatoid arthritis on immunosuppressant therapy presented with episodes of left-sided shaking and left gaze deviation with decreased level of consciousness. A preceding one-month history of complex visual hallucinations was subsequently elicited. Brain Computed Tomography (CT) perfusion and Magnetic Resonance Imaging (MRI) showed changes in the right parieto-occipital lobe that were consistent with possible seizure activity. Electr(..)

DOI: 10.7156/najms.2018.1101028

Published Online: 01-March-2018

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