Utility of chloroquine diphosphate in the blood bank laboratory

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 34 , ISSUE 3 (September 2018) > List of articles

Utility of chloroquine diphosphate in the blood bank laboratory

Thandar Aye * / Patricia A. Arndt

Keywords : chloroquine diphosphate, direct antiglobulin test, human leukocyte antigen

Citation Information : Immunohematology. Volume 34, Issue 3, Pages 98-102, DOI: https://doi.org/10.21307/immunohematology-2018-016

License : (Transfer of Copyright)

Published Online: 16-October-2019

ARTICLE

ABSTRACT

Chloroquine diphosphate (CDP) is a helpful tool in the blood bank for two main applications. The most common application is to render direct antiglobulin test–positive red blood cells (RBCs) free from membrane-bound IgG; these treated RBCs can then be used for autologous adsorption and/or to determine the patient’s RBC phenotype. Another common use of CDP is to remove human leukocyte antigens (HLAs) from RBCs to help identify or exclude the presence of antibodies to HLAs expressed on RBCs, for example, Bennett-Goodspeed (Bg) antigens. In this review, the principles, applications, and limitations of using CDP are discussed.

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