Red blood cell phenotype prevalence in blood donors who self-identify as Hispanic

Publications

Share / Export Citation / Email / Print / Text size:

Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

GET ALERTS SUBSCRIBE

ISSN: 0894-203X
eISSN: 1930-3955

DESCRIPTION

3
Reader(s)
3
Visit(s)
0
Comment(s)
0
Share(s)

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue / page

Archive
Volume 37 (2021)
Volume 36 (2020)
Volume 35 (2019)
Volume 34 (2018)
Volume 33 (2017)
Volume 32 (2016)
Volume 31 (2015)
Volume 30 (2014)
Volume 29 (2013)
Volume 28 (2012)
Volume 27 (2011)
Volume 26 (2010)
Volume 25 (2009)
Volume 24 (2008)
Volume 23 (2007)
Volume 22 (2006)
Volume 21 (2005)
Volume 20 (2004)
Volume 19 (2003)
Volume 18 (2002)
Volume 17 (2001)
Volume 16 (2000)
Volume 15 (1999)
Volume 14 (1998)
Volume 13 (1997)
Volume 12 (1996)
Volume 11 (1995)
Volume 10 (1994)
Volume 9 (1993)
Volume 8 (1992)
Volume 7 (1991)
Volume 6 (1990)
Volume 5 (1989)
Volume 4 (1988)
Volume 3 (1987)
Related articles

VOLUME 33 , ISSUE 3 (September 2017) > List of articles

Red blood cell phenotype prevalence in blood donors who self-identify as Hispanic

Chelsea A. Sheppard / Nicole L. Bolen / Beth Eades / Gorka Ochoa-Garay / Mark H. Yazer

Keywords : phenotype, Hispanic, blood donors

Citation Information : Immunohematology. Volume 33, Issue 3, Pages 119-124, DOI: https://doi.org/10.21307/immunohematology-2019-018

License : (Transfer of Copyright)

Published Online: 09-October-2019

ARTICLE

ABSTRACT

Molecular genotyping platforms provide a quick, high-throughput method for identifying red blood cell units for patients on extended phenotype-matching protocols, such as those with sickle cell disease or thalassemia. Most of the antigen prevalence data reported are for non-Hispanic populations. Therefore, this study sought to determine the phenotype prevalence in a single blood center’s Hispanic population and to compare those results with previously reported rates in non-Hispanic donor populations. We performed a retrospective review of all serologic and molecular typing from donors who self-reported as Hispanic. The phenotype prevalence was reported and compared with rates from other racial/ethnic groups. A total of 1127 donors who selfidentified as Hispanic were screened by serologic methods for Rh and Kell antigens, and 326 were subsequently selected for molecular typing. The most prevalent probable Rh phenotypes were R1r (26.6%), R1R2 (21.5%), and R1R1 (20.7%); rr was found in 7.8 percent of donors tested. The percentage of K+ donors in this population was 2.8 percent. The most prevalent Duffy phenotypes were Fy(a+b+) (35.9%), Fy(a+b–) (35.6%), and Fy(a–b+) (27%). Of the donors studied, 15.3 percent had an FY GATA mutation. Only 1.5 percent of the donors were Fy(a–b–). The Jk(a+b+) phenotype was found in nearly half of the population. M+N+S+s+ was the most prevalent MNS phenotype from that group, constituting 22.4 percent. A total of 95.7 percent of the donors were Lu(a–b+), and Di(a–b+) was observed in 94.4 percent. The most prevalent Dombrock phenotype was Do(a+b+), constituting 46.9 percent, followed closely by Do(a–b+) at 40.5 percent. Hispanic donor antigen prevalence is distinctly different from other racial/ethnic groups and should be considered when attempting to find extended matched units for these patients.

You don't have 'Full Text' access of this article.

Purchase Article Subscribe Journal Share