Suspected acute hemolytic transfusion reaction mediated by anti-Dia

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 31 , ISSUE 4 (December 2015) > List of articles

Suspected acute hemolytic transfusion reaction mediated by anti-Dia

Ashwini Bennett * / Ray K. Boyapati / Frank S. Hong

Keywords : Anti-Dia, transfusion reaction, low prevalence, alloantibodies  

Citation Information : Immunohematology. Volume 31, Issue 4, Pages 163-165, DOI: https://doi.org/10.21307/immunohematology-2019-087

License : (Transfer of Copyright)

Published Online: 26-October-2019

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ABSTRACT

Anti-Dia can mediate hemolytic disease of the fetus and newborn, but it is unclear if it can cause hemolytic transfusion reactions (HTRs). To date, there has only been one report of a possible immediate HTR attributed to anti-Dia. Our case report details an immediate HTR due to anti-Dia in a patient with pre-existing liver failure. This reaction triggered multi-organ failure, and the patient subsequently died. This case also highlights the importance of considering HTRs even when routine antibody screening has been unremarkable, particularly when electronic crossmatch is used, because of the potential for an alloantibody against a lowprevalence antigen.

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