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Citation Information : Immunohematology. Volume 6, Issue 2, Pages 27-29, DOI: https://doi.org/10.21307/immunohematology-2019-1036
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Published Online: 20-December-2020
Cromer-related blood group antigens are located on the complement regulatory glycoprotein, decay-accelerating factor (DAF). DAF is not detectable on red cells from individuals with a Cromernull phenotype (termed Inab), which is probably an inherited condition. DAF is also absent from a subpopulation of red cells (PNH III) from patients with paroxysmal nocturnal hemoglobinuria (PNH), an acquired hematological defect. PNH III red cells, like Inab cells, lack all the Cromer-related antigens described to date.