Two cases of autoantibodies that demonstrate mimicking specificity in the Duffy blood group system

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 6 , ISSUE 4 (December 1990) > List of articles

Two cases of autoantibodies that demonstrate mimicking specificity in the Duffy blood group system

Teresa Y. Harris

Citation Information : Immunohematology. Volume 6, Issue 4, Pages 87-91, DOI: https://doi.org/10.21307/immunohematology-2019-1050

License : (Transfer of Copyright)

Published Online: 20-December-2020

ARTICLE

ABSTRACT

Two transfused Caucasian patients presented with possible delayed transfusion reactions. Both patients demonstrated an anti-Fya (Fy1) plus anti-Fyb (Fy2) pattern of reactivity in their sera. The patients’ red blood cells (RBCs) were Fy:1,-2,3. Both had positive direct antiglobulin tests (DAT) with anti-IgG and -C3d. The serum antibodies reacted with the patients’ RBCs drawn when the DATs were negative. Both patients’ serum samples showed reactivity with Fy:1,-2 (1+), Fy:-1,2 (3+), Fy:1,2 (3+) RBCs at the antiglobulin phase (AGT) but were nonreactive with Fy: -1,- 2 RBCs. The anti­bodies in both cases were nonreactive with papain- or ficin-treated RBCs and reacted with Rhnull RBCs, which ruled out anti-Fy3 and anti-Fy5, respectively. These cases suggest mimicking autoantibody specificities in the Duffy system. One case may indicate that the degree of reactivity is dependent on the Duffy phenotype of the RBCs tested (Fy: -1,2 > Fy:1,2 > Fy: -1, -2). An unusual character­istic seen in both of these cases was hemolysis in the EDTA cell samples but none in the clotted samples.

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