An update on Rodgers and Chido, the antigenic determinants of human C4

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 5 , ISSUE 1 (March 1989) > List of articles

An update on Rodgers and Chido, the antigenic determinants of human C4

Carolyn M. Giles

Citation Information : Immunohematology. Volume 5, Issue 1, Pages 1-6, DOI: https://doi.org/10.21307/immunohematology-2019-1057

License : (Transfer of Copyright)

Published Online: 27-December-2020

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ABSTRACT

Rodgers (Rg) and Chido (Ch) blood groups are antigenic determinants of the fourth component of human complement (C4). Nine determinants have been defined by means of hemagglutination-inhibition (HAI) with polyspecific human antiserums. The association of C4A isotypes with Rg and of C4B isotypes with Ch is strong hut not complete. Derived amino acid sequences from the C4d region of selected C4 allotypes of known antigenic expression have provided support for the previously reported complex serologic interrelationships. A structural model for antigenic determinants at four polymorphic sites, incorporating sequential and conformational epitopes, was subsequently proposed. Allotype and Rg/Ch data obtained from donors and patients, many with accompanying families, have augmented the model and revealed no exceptions. The antigenic determinants, therefore, make an important contribution to the complex polymorphism of C4.

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