Detection and identification of plateletassociated alloantibodies by a solidphase modified antigen capture enzymelinked immunosorbent assay method and its correlation to platelet refractoriness in multiplatelet concentrate–transfused patients

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 30 , ISSUE 3 (September 2014) > List of articles

Detection and identification of plateletassociated alloantibodies by a solidphase modified antigen capture enzymelinked immunosorbent assay method and its correlation to platelet refractoriness in multiplatelet concentrate–transfused patients

Neelesh Jain / Ravi Shankar Sarkar / Joseph Philip

Keywords : HLA, platelet glycoproteins, platelet alloimmunization, MACE

Citation Information : Immunohematology. Volume 30, Issue 3, Pages 123-125, DOI: https://doi.org/10.21307/immunohematology-2019-107

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Published Online: 01-December-2019

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ABSTRACT

Platelets express a variety of polymorphic glycoproteins (GPs), such as GPIIb/IIIa, GPIb/IX, GPIa/IIa, GPIV, and class I human leukocyte antigen. In the platelet transfusion setting, alloimmunization involves the production of antibodies against these glycoproteins. Patients transfused with multiple units of platelet concentrates for longer periods are the main individuals with platelet alloimmunization. This study was performed to detect the development of platelet antibodies in patients who are transfused with multiple units of leukodepleted platelet concentrates, such as those with hemato-oncologic diseases and bone marrow failure syndromes. The method used was solidphase modified antigen capture enzyme-linked immunosorbent assay. Platelet refractoriness was assessed by measuring the corrected count increment at 1 and 24 hours after transfusion.

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