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Citation Information : Immunohematology. Volume 30, Issue 3, Pages 123-125, DOI: https://doi.org/10.21307/immunohematology-2019-107
License : (Transfer of Copyright)
Published Online: 01-December-2019
Platelets express a variety of polymorphic glycoproteins (GPs), such as GPIIb/IIIa, GPIb/IX, GPIa/IIa, GPIV, and class I human leukocyte antigen. In the platelet transfusion setting, alloimmunization involves the production of antibodies against these glycoproteins. Patients transfused with multiple units of platelet concentrates for longer periods are the main individuals with platelet alloimmunization. This study was performed to detect the development of platelet antibodies in patients who are transfused with multiple units of leukodepleted platelet concentrates, such as those with hemato-oncologic diseases and bone marrow failure syndromes. The method used was solidphase modified antigen capture enzyme-linked immunosorbent assay. Platelet refractoriness was assessed by measuring the corrected count increment at 1 and 24 hours after transfusion.