An update on the GLOB blood group system and collection

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 29 , ISSUE 1 (March 2013) > List of articles

An update on the GLOB blood group system and collection

Åsa Hellberg / Julia S. Westman / Martin L. Olsson

Citation Information : Immunohematology. Volume 29, Issue 1, Pages 19-24, DOI: https://doi.org/10.21307/immunohematology-2019-119

License : (Transfer of Copyright)

Published Online: 01-December-2019

ARTICLE

ABSTRACT

The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. The P antigen is intimately related to the Pk and NOR antigens discussed in the review about the P1PK blood group system. Naturally occurring anti-P is present in the serum of individuals with the rare globosidedeficient phenotypes p, P1k, and P2k and has been implicated in hemolytic transfusion reactions as well as unfavorable outcomes of pregnancy. The molecular genetic basis of globoside deficiency is absence of functional P synthase as a result of mutations at the B3GALNT1 locus. Other related glycolipid structures, the LKE and PX2 antigens, remain in the GLOB blood group collection pending further evidence about the genes and gene products responsible for their synthesis.

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