Cartwright blood group system review

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 28 , ISSUE 2 (June 2012) > List of articles

Cartwright blood group system review

Melissa R. George

Keywords : Cartwright, Yt, AChE

Citation Information : Immunohematology. Volume 28, Issue 2, Pages 49-54, DOI: https://doi.org/10.21307/immunohematology-2019-149

License : (Transfer of Copyright)

Published Online: 01-December-2019

ARTICLE

ABSTRACT

The Cartwright (Yt) blood group system consists of two antigens, Yta and Ytb, that result from point mutations in the acetylcholinesterase gene on chromosome 7q. Yta is a highincidence antigen, whereas its antithetical antigen, Ytb, shows much lower incidence. Anti-Yta and anti-Ytb are relatively rare. Anti-Yta is more commonly found in individuals of Jewish descent. Cartwright antibodies are rarely clinically significant; however, cases of in vivo hemolysis have been reported, suggesting that clinical significance should be interpreted on a case-by-case basis.

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