Weak D type 42 cases found in individuals of European descent

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 27 , ISSUE 1 (March 2011) > List of articles

Weak D type 42 cases found in individuals of European descent

Maryse St-Louis / Martine Richard / Marie Côté / Carole Éthier / Anne Long

Keywords : Weak D, RH genotyping, anti-D, alloimmunization, Caucasians

Citation Information : Immunohematology. Volume 27, Issue 1, Pages 20-24, DOI: https://doi.org/10.21307/immunohematology-2019-170

License : (Transfer of Copyright)

Published Online: 01-December-2019

ARTICLE

ABSTRACT

Patient samples were referred to our immunohematology reference laboratory to investigate the presence of a weak D antigen. In the last 3 years, 26 samples were received. Serology and molecular analyses were performed to identify the weak D variant. RHD mRNA from all patients was reverse transcribed, and cDNA was sequenced. The results were compared with a normal RHD sequence to identify the polymorphisms causing the weak D phenotype. Five different already known RHD variants were observed: weak D type 1 (5 individuals), weak D type 2 (1 individual), weak D type 42 (17 individuals), weak D type 45 (1 individual), and partial D DNB (2 individuals). Surprisingly, weak D type 42 was prevalent in our population, whereas weak D type 1, 2, and 3 are the most prevalent variants elsewhere. Anti-D was found in six cases of weak D type 42. The higher prevalence of weak D type 42 could be the result of a founder effect. Additional studies are needed to estimate the frequency of this variant in the general population.

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