Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: a case study and review

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 27 , ISSUE 3 (September 2011) > List of articles

Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: a case study and review

George Grigoriadis / Jennifer Condon / Kate Green / Mary Ann Anderson / Marija Borosak / Erica Wood

Keywords : anti-AnWj, lymphoma, hemolysis

Citation Information : Immunohematology. Volume 27, Issue 3, Pages 83-88, DOI: https://doi.org/10.21307/immunohematology-2019-179

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Published Online: 11-March-2020

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ABSTRACT

AnWj is a high-incidence antigen present on the red blood cells (RBCs) of greater than 99 percent of the general population. A 58-year-old man underwent autologous hematopoietic stem cell transplantation (HSCT) for stage IVa mantle cell lymphoma. This procedure was complicated by failure to engraft, necessitating ongoing support with blood components. After a 2-month period of uneventful transfusion support, the patient experienced increasingly severe reactions with fever and evidence of intravascular hemolysis, including hemoglobinuria. Testing revealed a complement-dependent anti-AnWj. Phenotyping confirmed the AnWj– phenotype. Anti-AnWj was persistent despite immunosuppression, including treatment with allogeneic HSCT. Of interest, the pathogenesis of the downregulation of the graft AnWj in this patient is unclear.

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