An unusual case of an acute hemolytic transfusion reaction caused by an autoanti-I

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 27 , ISSUE 3 (September 2011) > List of articles

An unusual case of an acute hemolytic transfusion reaction caused by an autoanti-I

Nay Win / Sally Rahman / Philip Gold / Susan Ward

Keywords : autoanti-I, acute hemolytic transfusion reaction, cold autoagglutinins

Citation Information : Immunohematology. Volume 27, Issue 3, Pages 101-103, DOI: https://doi.org/10.21307/immunohematology-2019-182

License : (Transfer of Copyright)

Published Online: 11-March-2020

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ABSTRACT

In general, naturally occurring cold autoagglutinins react optimally at low temperatures. We describe a young child who experienced an acute hemolytic transfusion reaction by an unusual autoanti-I. The IgM autoanti-I was detected at 4°C (titer 256) and also reacted at 30°C. This case highlights the potential hazard of transfusing units of blood immediately upon removal from the blood refrigerator, especially into neonates and children of small stature.

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