Occurrence of antibodies to low-incidence antigens among a cohort of multiply transfused patients with sickle cell disease

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 27 , ISSUE 4 (December 2011) > List of articles

Occurrence of antibodies to low-incidence antigens among a cohort of multiply transfused patients with sickle cell disease

Pamela Jackson

Keywords : sickle cell disease, low-incidence antigens, alloantibodies

Citation Information : Immunohematology. Volume 27, Issue 4, Pages 143-145, DOI: https://doi.org/10.21307/immunohematology-2019-188

License : (Transfer of Copyright)

Published Online: 12-March-2020

ARTICLE

ABSTRACT

Data from an immunohematology reference laboratory were compiled retrospectively to determine the occurrence of the formation of alloantibodies to low-incidence antigens associated with the African American population (AA-LIAs) among patients with sickle cell disease (SCD). The AA-LIAs under study were V, VS, Jsa, and Goa. The records from 137 recurrently transfused patients with SCD were selected on the basis of transfusion activity from the 2009 calendar year. We found that 13 patients (9.49%) exhibited one or more antibodies to AA-LIAs, and a total of 17 antibodies to these AA-LIAs have been developed by these patients. The occurrence of antibody formation to AA-LIAs is significantly greater than that of alloantibodies to low-incidence antigens in the general population. Considering the possibility of the presence of antibodies to AA-LIAs in multiply transfused patients with SCD is warranted.

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