Serologic and molecular characterization of the B(A) blood group in the Chinese population

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 23 , ISSUE 2 (June 2007) > List of articles

Serologic and molecular characterization of the B(A) blood group in the Chinese population

Zhong-Hui Guo / Dong Xiang / Zi-Yan Zhu / Xi Liu / He-Ping Chen / Jian-Lian Wang / Da-Zhuang Liu / Tong-Mao Zhao

Keywords : ABO subtype, B(A) phenotype, B(A) allele, PCR-SSP genotyping

Citation Information : Immunohematology. Volume 23, Issue 2, Pages 69-74, DOI: https://doi.org/10.21307/immunohematology-2019-323

License : (Transfer of Copyright)

Published Online: 01-April-2020

ARTICLE

ABSTRACT

B(A) phenotype individuals have normal B antigen and a small amount of A antigen on the RBCs with anti-A in the plasma. Some highly potent monoclonal anti-A reagents are capable of agglutinating B(A) RBCs,which therefore usually results in a discrepancy between RBC and plasma ABO grouping. To date,five B(A) alleles (ABO*B(A)01, B(A)02, B(A)03, B(A)04, and B(A)05) have been defined by nucleotide sequences. To get a more complete picture of B(A) phenotypes found in the Chinese population and resolve blood donor typing problems caused by B(A) alleles,a serologic and molecular study of nine unrelated Chinese individuals and three families carrying B(A) alleles was conducted. Allele B(A)02 with a 700C>G mutation,allele B(A)04 with a single 640A>G substitution, and allele B(A)05 with a 641T>C mutation were detected in multigenerational families and unrelated blood donors. Neither the B(A)01 nor B(A)03 alleles with 703A>G substitutions were observed in this study. In addition, a polymerase chain reaction with a sequence-specific primer genotyping assay was developed for rapid identification of B(A)02, B(A)04, and B(A)05 alleles using genomic DNA samples.

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