Management of pregnancy complicated by anti-hrB/anti-HrB

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 23 , ISSUE 4 (December 2007) > List of articles

Management of pregnancy complicated by anti-hrB/anti-HrB

Nay Win / Malcolm Needs / Louise Tillyer

Keywords : Anti-HrB, anti-hrB, hemolytic transfusion reactions, hemolytic disease of the newborn

Citation Information : Immunohematology. Volume 23, Issue 4, Pages 143-145, DOI: https://doi.org/10.21307/immunohematology-2019-331

License : (Transfer of Copyright)

Published Online: 01-April-2020

ARTICLE

ABSTRACT

Anti-hrB and anti-HrB are rare alloantibodies found predominantly in people of BlackAfrican descent. It has been assumed that strongly reacting examples of anti-hrB may cause hemolytic transfusion reactions,but precise information is limited. Anti-HrB is a clinically significant antibody and may cause hemolytic transfusion reactions and HDN. Selection of blood for transfusion support for patients with these alloantibodies, and especially with anti-HrB, imposes a special challenge in the United Kingdom. We report two antenatal patients (both patients were of the partial D phenotype DIII),one with anti-hrB,anti-Ce,and anti-D;the other,with anti-hrB and anti-D, who later formed anti-HrB. Transfusion support and the outcome of the pregnancies are discussed. Aliterature search confirms that,apart from some publications in abstract form,there is not much detailed clinical information available for either anti-hrB or anti-HrB. Further information and publications are warranted to gain more knowledge of these rare antibodies.

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