Case report: DNA testing resolves unusual serologic results in the Dombrock system

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 22 , ISSUE 2 (June 2006) > List of articles

Case report: DNA testing resolves unusual serologic results in the Dombrock system

Diane MacFarland / Kim Hue-Roye / Scott Carter / Dawn Moreau / James Barry / Marilyn K. Moulds / Christine Lomas-Francis / Marion E. Reid

Keywords : blood groups, Dombrock, transfusion medicine, DNA-based assay, molecular typing

Citation Information : Immunohematology. Volume 22, Issue 2, Pages 69-71, DOI: https://doi.org/10.21307/immunohematology-2019-349

License : (Transfer of Copyright)

Published Online: 13-April-2020

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ABSTRACT

Typing for antigens in the Dombrock blood group system and identifying the corresponding antibodies are notoriously difficult tasks. The reagents are scarce and the antibodies are weakly reactive. When RBCs from family members of a patient with an antibody to a high-prevalence Dombrock antigen were tested for compatibility,an unusual pattern of inheritance was observed:RBCs from the patient’s children and one niece,in addition to those from some of the patient’s siblings,were compatible. This prompted the performance of DNA-based assays for DO alleles and the results obtained were consistent with and explained the compatibility test results. It was possible to study this large kindred because of the cooperation of family members, hospital personnel, and reference laboratory staff.

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