Review: molecular basis of MNS blood group variants

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 22 , ISSUE 4 (December 2006) > List of articles

Review: molecular basis of MNS blood group variants

P. Palacajornsuk

Keywords : MNS blood group, MNS antigens, glycophorin genes, hybrid glycophorins, genetic mechanism, molecular basis

Citation Information : Immunohematology. Volume 22, Issue 4, Pages 171-182, DOI: https://doi.org/10.21307/immunohematology-2019-377

License : (Transfer of Copyright)

Published Online: 15-April-2020

ARTICLE

ABSTRACT

The MNS blood group antigens are expressed in the RBC membrane on glycophorin A (GPA), glycophorin B (GPB), or combinations of both. GPA expresses the M or N antigen,whereas GPB expresses the S or s antigen and the N antigen (′N′). Both glycophorin genes (GYPA and GYPB) are located on the long arm of chromosome 4 and share 95 percent sequence identity. This high degree of sequence identity, together with the rare involvement of a third homologous gene (GYPE), provides an increased chance of recombination, resulting in hybrid molecules that often carry one or more novel antigens. Some of the antigens in the MNS system result from a single nucleotide substitution. The MNS blood group system now consists of more than 40 distinct antigens. This review summarizes the molecular basis associated with some of the antigens in the MNS blood group system.

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