Gene frequencies of the HPA-1 to 6 and Gov human platelet antigens in Thai blood donors

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 21 , ISSUE 1 (March 2005) > List of articles

Gene frequencies of the HPA-1 to 6 and Gov human platelet antigens in Thai blood donors

Pawinee Kupatawintu / Oytip Nathalang / Rachanee O-Charoen / Pimpicha Patmasiriwat

Keywords : human platelet antigen (HPA), Gov, PCRSSP, Thais, gene frequencies

Citation Information : Immunohematology. Volume 21, Issue 1, Pages 5-9, DOI: https://doi.org/10.21307/immunohematology-2019-385

License : (Transfer of Copyright)

Published Online: 20-April-2020

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ABSTRACT

Human platelet alloantigens (HPA) are important in neonatal alloimmune thrombocytopenia (NAIT), posttransfusion purpura (PTP), platelet transfusion refractoriness, passive alloimmune thrombocytopenia, and transplantation-associated alloimmune thrombocytopenia. Thus, HPA genotyping is essential in diagnosis and treatment. We analyzed HPA-1 to 6 and Gov alleles, using PCR with sequence specific primers (PCR-SSP) in 500 Thai blood donors who had been HLA class I antigen typed. HPA-4a was present in all samples. HPA-1b, -2b, -5b, and -6b were rare,and HPA-4b was not found. HPA-3a and -3b showed frequencies of 56.0 percent and 44.0 percent, respectively. Gova and Govb showed frequencies of 49.1 percent and 50.9 percent, respectively. The prevalence rates of HPA-1 to 6 gene frequencies (GFs) were consistent with those of other Asian populations rather than those of Caucasians. We also report on the GFs of Gova and Govb, which also are comparable to those of Asian populations. Our results could establish a useful HPA- and HLA-matched plateletpheresis donor file and provide an improvement of platelet alloantibody detection in alloimmune thrombocytopenic patients,and,therefore,a more effective platelet transfusion program.

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