Low-incidence MNS antigens associated with single amino acid changes and their susceptibility to enzyme treatment

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 17 , ISSUE 3 (September 2001) > List of articles

Low-incidence MNS antigens associated with single amino acid changes and their susceptibility to enzyme treatment

Marion E. Reid / Jill Storry

Keywords : MNS blood group system, low-incidence antigens, molecular basis, enzymes, papain, trypsin, α-chymotrypsin, ficin

Citation Information : Immunohematology. Volume 17, Issue 3, Pages 76-81, DOI: https://doi.org/10.21307/immunohematology-2019-551

License : (Transfer of Copyright)

Published Online: 14-October-2020

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ABSTRACT

MNS antigens are carried on glycophorin A (GPA), glycophorin B (GPB), or their variants. Antigens at the N-terminus of GPA are sensitive to cleavage by ficin, papain, and trypsin but are resistant to α-chymotrypsin. Antigens at the N-terminus of GPB are sensitive to cleavage by ficin, papain, and α-chymotrypsin but are resistant to trypsin treatment. These characteristics have been used to aid in the identification of blood group alloantibodies. Recent molecular analyses have identified changes in amino acids that are associated with several low-incidence antigens in the MNS blood group system. This review relates the molecular studies with the susceptibility or resistance of these antigens to treatment of intact red blood cells by proteolytic enzymes.

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