Evaluation of the GTI-ASP-1 platelet antigen genotyping kit for the determination of the HPA-1 genotype

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 14 , ISSUE 1 (March 1998) > List of articles

Evaluation of the GTI-ASP-1 platelet antigen genotyping kit for the determination of the HPA-1 genotype

Tobias J. Legler / Christopher Hagner / Michael Köhler

Keywords : HPA-1, genotype, PCR-SSP, ligationbased typing

Citation Information : Immunohematology. Volume 14, Issue 1, Pages 19-21, DOI: https://doi.org/10.21307/immunohematology-2019-648

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Published Online: 03-November-2020

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ABSTRACT

The human platelet antigen system HPA-1 is involved in most cases of neonatal alloimmune thrombocytopenia and posttransfusion purpura, and occasionally causes refractoriness to platelet transfusions. Complete concordance was obtained in genotyping for HPA-1 in all samples tested with the HPA-1 genotyping kit and a ligation-based typing method. However, the genotyping kit is less sensitive than ligation-based typing, which could be of importance when testing cells from amnionic fluid or from chorionic villi.

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