The second example of Lu:-7 phenotype: serology and immunochemical studies

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 12 , ISSUE 2 (June 1996) > List of articles

The second example of Lu:-7 phenotype: serology and immunochemical studies

Marion E. Reid / Jack L. Hoffer / Ragnhild Øyen / Edith Alicea-Tossas / Manijeh Sadjadi / Gladys M. Messina

Citation Information : Immunohematology. Volume 12, Issue 2, Pages 66-68, DOI: https://doi.org/10.21307/immunohematology-2019-748

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Published Online: 10-November-2020

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ABSTRACT

We describe the second example of red blood cells (RBCs) with the Lu:–7 phenotype in a 37-year-old Latino female (SA). Her RBCs were nonreactive with anti-Lu7 (Mrs. GA) but were reactive with all other antibodies to high-prevalence antigens tested, including those in the Lutheran blood group system. No Lu:–7 RBCs were available for testing. SA’s serum was nonreactive by the indirect antiglobulin test against (1) recessive and dominant Lu(a–b–) RBCs and (2) trypsin-treated or α-chymotrypsin-treated RBCs of common phenotype. By immunoblotting, eluates containing anti-Lu7 from both Mrs. GA and SA reacted with apparently the same bands in RBC membranes of common phenotype as did human anti-Lub, reacted weakly with Lu(a–b–) RBCs of the dominant type, and were nonreactive with SA’s RBC membranes. These findings raise the Lu7 antigen from its Lutheran-related (para-Lutheran) status to a bona fide member of the Lutheran blood group system.

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