First example of Rh:-32,-46 red cell phenotype

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 10 , ISSUE 4 (December 1994) > List of articles

First example of Rh:-32,-46 red cell phenotype

Jill Storry / Michael Gorman / Nancy I. Maddox / Ella Toy / Peter D. Issitt / Delores M. Mallory

Citation Information : Immunohematology. Volume 10, Issue 4, Pages 130-133, DOI: https://doi.org/10.21307/immunohematology-2019-939

License : (Transfer of Copyright)

Published Online: 30-November-2020

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ABSTRACT

The red cells of a white male blood donor typed as Rh:-1, -2, -3, w4, w5, 6, -17, w19, -31, -32, -34, and -46. Although the donor has no history of transfusion, his serum contains an alloantibody that is weakly reactive with most red blood cells (RBCs) tested. Only Rhnull and D-- RBCs are nonreactive. Reactivity is enhanced with ficin- or papain-treated RBCs and is unaffected by AET or DTT treatment of the RBCs. Previously described Rh:-46 RBCs have been of deletion types D--, D••, and Rhnull, or Rh:32. In three multitransfused patients, the Rh46 antigen was temporarily suppressed and the phenotype eventually reverted to normal. This is the first report of RBCs of the Rh:-32,-46 phenotype that are not of a rare Rh deletion or Rhnull type. In addition, the Rh:w5, w19, -31, -34 phenotype is rarely fonnd in whites.

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