Loss and reappearance of RhO(D) antigen on the red blood cells of an individual with acute myelogenous leukemia

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 10 , ISSUE 4 (December 1994) > List of articles

Loss and reappearance of RhO(D) antigen on the red blood cells of an individual with acute myelogenous leukemia

Kala Mohandas / Vesna Najfeld / Harriet Gilbert / Penny Azar / Donna Skerrett

Citation Information : Immunohematology. Volume 10, Issue 4, Pages 134-135, DOI: https://doi.org/10.21307/immunohematology-2019-940

License : (Transfer of Copyright)

Published Online: 30-November-2020

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ABSTRACT

Complete loss of Rho(D) antigen from red blood cells (RBCs) of individuals with hematologic disorders, though not frequent, has been reported. This case reports the loss of D antigen on the RBCs of a patient with acute myelogenous leukemia and its reappearance when he was in remission. Loss of D antigen expression coincided with worsening clinical and cytogenetic disease. At the time of D antigen loss, the patient also had cytogenetic abnormalities in the bone marrow cells. When he was in remission, the chromosomal abnormalities were no longer detectable, and his RBCs regained D antigen expression.

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