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Citation Information : Immunohematology. Volume 9, Issue 1, Pages 19-21, DOI: https://doi.org/10.21307/immunohematology-2019-951
License : (Transfer of Copyright)
Published Online: 06-December-2020
Plasma converted to serum by the addition of bovine thrombin prior to compatibility testing agglutinated all donor red cells. This finding prompted an investigation of bovine thrombin-associated incompatibility that showed that (1) thrombin derived from bovine plasma contains IgG antibodies directed against all human red cells, and (2) excess (> 50 units/mL) bovine thrombin used for conversion of plasma to serum may cause hemagglutination and erroneous serologic test results because of the presence of heteroagglutinins.