An update on the H blood group system

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 35 , ISSUE 2 (June 2019) > List of articles

An update on the H blood group system

E.A. Scharberg * / C. Olsen / P. Bugert

Keywords : H antigen, Bombay phenotype, Oh, FUT1

Citation Information : Immunohematology. Volume 35, Issue 2, Pages 67-68, DOI: https://doi.org/10.21307/immunohematology-2020-017

License : (Transfer of Copyright)

Published Online: 15-February-2021

ARTICLE

ABSTRACT

This update of the H blood group system (Scharberg EA, Olsen C, Bugert P. The H blood group system. Immunohematology 2016;32:112–8) reports 11 new FUT1 null alleles: 8 causative for the H– phenotype (Bombay phenotype, Oh), 3 in para-Bombay cases, and 5 new FUT1 alleles causative for a weak H phenotype (para-Bombay, H+w). The H blood group system (International Society of Blood Transfusion system 18) consists of a single antigen (H) defined by a terminal fucose residue found on red blood cells (RBCs) and in secretions. The H antigen is synthesized on the RBC surface by the FUT1 gene product fucosyltransferase 1. On epithelial cells and in body fluids, the H antigen is synthesized by the FUT2 gene product fucosyltransferase 2.

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