Anti-Ata in a renal transplant candidate: a case report

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Immunohematology

American National Red Cross

Subject: Medical Laboratory Technology

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ISSN: 0894-203X
eISSN: 1930-3955

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VOLUME 36 , ISSUE 3 (September 2020) > List of articles

Anti-Ata in a renal transplant candidate: a case report

J. Gao * / S. Wise / S.H. Tinsley / J.F. Shikle

Keywords : Augustine blood group system, renal transplantation, monocyte monolayer assay (MMA), polyethylene glycol (PEG), Ata

Citation Information : Immunohematology. Volume 36, Issue 3, Pages 104-107, DOI: https://doi.org/10.21307/immunohematology-2020-049

License : (Transfer of Copyright)

Published Online: 22-January-2021

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ABSTRACT

A patient with end-stage renal disease on chronic dialysis was admitted to the hospital for renal transplantation evaluation. Blood type and antibody detection tests were performed. The antibody detection test results were positive. Initial antibody identification studies indicated the presence of a panagglutinin. The patient’s autocontrol was negative. The antibody was subsequently identified by a reference laboratory as anti-Ata (Augustine), which is an extremely rare antibody due to the high prevalence of Ata in the general population. A monocyte monolayer assay (MMA) was performed to assess the clinical significance of the antibody in the event that blood was needed for transfusion, and At(a–) RBCs were not available. The MMA results predicted the antibody to be capable of causing hemolysis in vivo. A brief historical review of the incidence and clinical significance of this antibody is included in this case report.

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