Inspection of Solid Dosage Forms using  THz Imaging Spectroscopy

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International Journal on Smart Sensing and Intelligent Systems

Professor Subhas Chandra Mukhopadhyay

Exeley Inc. (New York)

Subject: Computational Science & Engineering, Engineering, Electrical & Electronic

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VOLUME 7 , ISSUE 5 (December 2014) > List of articles

Special issue ICST 2014

Inspection of Solid Dosage Forms using  THz Imaging Spectroscopy

T. Arnold * / M. De Biasio / A. Fritz / R. Leitner

Keywords : terahertz;  imaging;  spectroscopy

Citation Information : International Journal on Smart Sensing and Intelligent Systems. Volume 7, Issue 5, Pages 1-4, DOI: https://doi.org/10.21307/ijssis-2019-085

License : (CC BY-NC-ND 4.0)

Published Online: 15-February-2020

ARTICLE

ABSTRACT

The present work describes a laboratory terahertz (THz) imaging spectroscopy system and its possibilities to inspect solid dosage forms in the form of coated tablets and capsules. Moreover, the chemical composition and layer structure of coated pharmaceutical tablets are investigated. These chemical and physical properties of solid dosage forms can be used for the detection of counterfeit drugs. Preliminary results show that THz time domain spectroscopy and imaging is a promising technology for contactless control and analysis of pharmaceutical drug materials and final dosage forms.

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REFERENCES

[1] World Health Organization, "Fact sheet N°275", vol. 2, pp. 330-340, Nov 2006.  
 
[2] M. C. Beard and M. G. Turner and C. A. Schmuttenmaer, "Terahertz Spectroscopy", in Journal of Physical Chemistry, vol. 106, pp 7146-7159, 2002.
 
[3] J. A. Zeitler and P. F. Taday and D. A. Newnham and M. Pepper and K. C. Gordon and T. Rades, " Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting- a review", in Journal of Pharmacy and Pharmacology, vol. 59, pp. 209-223, 2007.
 
[4] Y. C. Shen and P. F. Taday and D. A. Newnham and M. C. Kemp and M. Pepper, "3D chemical mapping using terahertz pulsed imaging", in Terahertz and Gigahertz Electronics and Photonics IV, pp.24-31, 2005, San Jose, CA.
 
[5] J. A. Zeitler and Y. C. Shen and C. Baker and P. F. Taday and M. Pepper, "Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging", in J. Pharm. Sci., vol.96(2), pp.330-340, 2007.
 
[6] J. Fitzgerald and B. E. Cole and P. F. Taday, "Nondestructive analysis of tablet coating thickness using terahertz pulsed imaging", in J. Pharm. Sci., vol. 94, pp.177-183, 2005.

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