The epileptic multifactorial patient’s burden. Review of the topic

Publications

Share / Export Citation / Email / Print / Text size:

Journal of Epileptology

Foundation of Epileptology

Subject: Medicine

GET ALERTS

eISSN: 2300-0147

DESCRIPTION

3
Reader(s)
7
Visit(s)
0
Comment(s)
0
Share(s)

SEARCH WITHIN CONTENT

FIND ARTICLE

Volume / Issue / page

Archive
Volume 26 (2018)
Volume 25 (2017)
Volume 24 (2016)
Volume 23 (2015)
Volume 22 (2014)
Volume 21 (2013)
Related articles

VOLUME 24 , ISSUE 2 (December 2016) > List of articles

The epileptic multifactorial patient’s burden. Review of the topic

José Pimentel *

Keywords : comorbidity, epilepsy, seizures, quality of life, social stigma

Citation Information : Journal of Epileptology. Volume 24, Issue 2, Pages 167-172, DOI: https://doi.org/10.1515/joepi-2016-0009

License : (CC BY 4.0)

Received Date : 08-August-2016 / Accepted: 23-September-2016 / Published Online: 30-September-2016

ARTICLE

ABSTRACT

Background. Approximately 26% of the burden of neurologic diseases is due to epilepsy. Its negative impact reflects mainly on people with epilepsy (PWE) themselves.

Aims. To highlight the negative impacts of epilepsy on the lives of PEWs so as to identify a realistic approach to their individual needs.

Methods. For recently published papers PubMed and MEDLINE databases were used. In addition relevant references mentioned in the searched articles were also considered.

Review and discussion. Generalized tonic-clonic seizures and refractory epilepsy are the most important factors burdening PWE’s, resulting in increased injuries and mortality, including Sudden Unexpected Death in Epilepsy (SUDEP). The need of chronic intake of antiepileptic drugs (AEDs) and of epilepsy surgery are also important with regards to potential for side effects, drug interactions, and different surgery risks. PWE harbour more medical and psychiatric comorbidities than the general population and results in a decreased quality of life. Decreased self-esteem and major stigma are also frequent, linked to social, economic and personal negative consequences. Age also plays a role, younger people being more stigmatized given the interdiction to drive or difficulty in getting a job. In the elderly, seizures may have an impact on mental status, mood and sleep. Gender may also contribute, particularly involving women in childbearing age, linked to the fear or depression due to the possibility of AED-induced fertility disturbances, foetal malformations, or breast feeding sideeffects.

Conclusions. The burden that PWE face must be considered by all people involved in the management of their epilepsy. The causes may be multifactorial, all interconnected and each one influencing the others.

Content not available PDF Share

FIGURES & TABLES

REFERENCES

Baker G.A., Jacoby A., Buck D., Stalgis C., Monnet D.: Quality of life of people with epilepsy: a European study. Epilepsia, 1997, 38: 353–362.

 

Klein P., Tyrlikova I., Mathews G.C.: Dietary treatment in adults with refractory epilepsy: a review. Neurology, 2014, 83: 1978–1985.

 

Gaitatzis A., Carroll K., Majeed A., Sander J.W.: The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia, 2004, 45: 1613–1622.

 

World Health Organization (WHO): Disease Burden: Regional Estimates for 2011. Available at www.who.int/healthinfo/global_burden_disease/estimates_regional/en/index1.html, Accessed Jan.7, 2014.

 

Baumeister H., Balke K., Harter M.: Psychiatric and somatic comorbidities are negatively associated with quality of life in physically ill patients. J. Clin. Epidemiol., 2005, 58: 1090–1100.

 

Beghi E., Cornaggia C., RESt-1 Group.: Morbidity and accidents in patients with epilepsy: results of a European cohort study. Epilepsia, 2002, 43: 1076–1083.

 

Chong L., Jamieson J.J., Gill D., Singh-Grewal D., Craig C., Angela J.U.: Children’s experience of epilepsy: A systematic review. Pediatrics, 2016, 138 e20160658; DOI-10.1542/peds.2016–0618.

 

Elafros M.A., Sakubita-Simasihu C., Atadzhanov M., Haworth A., Chomba E., Birbeck G.L: Stigma and psychiatric morbidity among mothers of children with epilepsy on Zambia. Int. Health, 2013, 5: 288–294.

 

Fernandes C.T., Snape D.A., Beran R.G., Jacoby A.: Epilepsy stigma: what do we know and were next? Epilepsy Behav., 2011, 22: 55–62.

 

Gupta S., Kwan P., Faught E., Tsong W., Forsythe A., Ryvlin P.: Understanding the burden of idiopathic generalized epilepsy in the United States, Europe, and Brazil: An analysis from the National Health and Wellness Survey. Epilepsy Behav., 2016, 55: 146–156.

 

Hant S.R., Katz M., Masur J., Lipton R.B.: Seizures in the elderly: impact on mental status, mood and sleep. Epilepsy Behav., 2009, 14: 540–544.

 

Jacoby A.: Epilepsy and stigma: an update and critical review. Curr. Neurol. Neurosc. Rep., 2008, 8: 339–344.

 

Kerr MP.: The impact of epilepsy on patients’ lives. Acta. Neurol. Scand., 2012, 126 (Suppl. 194): 1–9.

 

Kessler R.C., Lane M.C., Shahly V., Stang P.E.: Accounting for comorbidity in assessing the burden of epilepsy among US adults: results from the National Comorbidity Survey Replication (NCS-R). Mol. Psychiatry, 2012, 17: 748–758.

 

Laxer K.D., Trinka E., Hirsch L.J., Cendes F., Langfitt J., Delanty N. et al.: The consequences of refractory epilepsy and its treatment. Epilepsy Behav., 2014, 37: 59–70.

 

Luoni C., Bisulli F., Canevini M.P., SOPHIE Study Group et al.: Determinants of health-related quality of life in pharmacoresistent epilepsy: results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments. Epilepsia, 2011, 52: 2181–2191.

 

Newton C.R., Garcia H.H.: Epilepsy in poor regions of the word. Lancet, 2012, 380: 1193–1201.

 

Perucca E., Gilliam F.G., Schmitz B.: Epilepsy treatment as a predeterminant of psychological ill health. Epilepsia Behav., 2009, 15 (Suppl. 1): S46–S50.

 

Sarkis R.A., Pietras A.C., Cheung A., Baslet G., Dworetzky B.: Neuropsychological and psychiatric outcomes in poorly controlled idiopathic generalized epilepsy. Epilespy Behav., 2013, 28: 370–373.

 

Schneider-von Podewils F., Gasse C., Geithner J., Wang Z.I., Bombach P., Berneiser J. et al.: Clinical predictors of long-term social outcome and quality of life in juvenile myoclonic epilepsy: 20–65 years of follow-up. Epilepsia, 2014, 55: 322–330.

 

Téllez-Zenteno J.F., Hunter G., Wiebe S.: Injuries in people with self-reported epilepsy: a population-based study. Epilepsia, 2008, 49: 954–961.

 

Thapar A., Kerr M., Harold G.: Stress, anxiety, depression, and epilepsy: investigating the relationship between psychological factors and seizures. Epilepsia, 2009, 14: 134–140.

 

Thurman D.J., Hesdorffer D.C., French J.A.: Sudden unexpected death in epilepsy: Assembling the public health burden. Epilepsia, 2014, 55: 1479–1485.

 

Tomson T., Walczac T., Sillanpaa M., Sander J.W.: Sudden unexpected death in epilepsy: a review of incidence and risk factors. Epilepsia, 2005, 46 (Suppl. 11): 54–61.

 

Villanueva V., Girón J.M., Martín J., Hernández-Pastor L.J., Lahuerta J., Doz M. et al.: Quality of life and economic impact of refractory epilepsy in Spain: The ESPERA Study. Neurologia, 2013, 28: 195–204.

 

World Health Organization (WHO): Neurological Disorders: Public Health Challenges. World Health Organization, Geneva 2006.

 

EXTRA FILES

COMMENTS